Senior Clinical Data Manager - Real World Evidence

Join us in our mission to revolutionize cancer detection and treatment! At GRAIL, we're at the forefront of groundbreaking technologies aimed at early cancer detection, utilizing next-generation sequencing (NGS), comprehensive clinical studies, and advanced data science. Our vibrant multidisciplinary team comprises dedicated scientists, engineers, and medical professionals all working tirelessly to change the landscape of cancer care. Based in Menlo Park, California, and transitioning to Sunnyvale in Fall 2026, we offer a flexible work arrangement that balances in-office collaboration and remote work. We encourage on-site participation particularly on key days like Tuesdays and Thursdays, to foster engagement in various team activities. Your Role: Collaborate with study team members to ensure accuracy and consistency in clinical and real-world data across all sources. Lead study startup activities, including protocol review, Clinical Data Management Plan (CDMP) creation, and EDC setup, integrating external and real-world data sources. Oversee study conduct activities by facilitating data reviews, documenting handling decisions, issuing queries, and resolving discrepancies. Apply programming skills to develop listings and dashboards needed by team members, including reconciling external datasets. Ensure proper data locking efforts and compliance with the CDMP, along with review and documentation of all data sources. Maintain data integrity throughout the data lifecycle, encompassing clinical data, bio-specimen storage data, and real-world datasets. Keep documentation audit-ready and properly organized within the Trial Master File. Collaborate with external data providers to create and/or review Data Transfer Plans (DTPs). Assist in the development and implementation of data standards and procedural documents in support of clinical data management. What We’re Looking For: A Bachelor’s degree with 5+ years of experience in clinical data management within an FDA-regulated environment, especially with real-world data (RWD) or evidence (RWE). Experience with IDE trials and device registries is essential. Demonstrated ability to lead clinical trials and manage multiple projects simultaneously. Solid understanding of RWD and RWE. Knowledge of regulatory requirements (ICH, GCP, HIPAA). Strong communication and organizational skills with a proven track record as a team player. Committed to achieving team goals with a sense of urgency. Experience in managing vendor relationships to ensure compliance with contracts. Familiarity with data visualization and analytics tools (e.g., Tableau) is preferred. Previous experience in the sponsor role is required, along with the ability to develop SOPs collaboratively. Preferred Qualifications: An advanced degree in epidemiology or informatics is preferred. Strong understanding of programming and analytics. Experience with EDC systems, including some EDC build experience, is a plus. Familiarity with programming languages such as R, SAS, or Python is advantageous. Experience in molecular diagnostics is a significant advantage. Physical Demands and Work Environment: Flexibility in hours and days based on operational needs. Ability to stand or sit for extended periods. May involve lifting up to 25 pounds. Open to a minimum of 40% on-site presence (24 hours per week). The expected annual base pay for this position is $109K - $144K. Actual compensation will vary based on experience and skills. This role may also include an annual bonus and is part of GRAIL's competitive benefits package, featuring flexible time off, retirement plans with employer match, and comprehensive health coverage. GRAIL is dedicated to building an inclusive work environment. All qualified applicants will receive fair consideration for employment regardless of race, color, religion, gender identity, sexual orientation, age, disability, or veteran status, in compliance with applicable laws. We encourage candidates from all backgrounds to apply and welcome inquiries regarding accommodations for applicants with disabilities. GRAIL promotes a drug-free workplace and values diverse job-seekers who aspire to contribute to our mission.

Created: 2026-03-08