Vice President Clinical Development

Vice President, Clinical DevelopmentLocation: Cambridge, MA (onsite minimum 3 days per week; hybrid flexibility outside of this)Employment Type: Full-time, Executive LeadershipAbout the Role:We are seeking an experienced Vice President of Clinical Development to lead the design, execution, and strategic direction of our clinical programs in oncology and advanced therapeutics. This individual will join the executive leadership team and play a pivotal role in translating cutting-edge science into transformative medicines for patients with high unmet need.The VP, Clinical Development will oversee the clinical portfolio from early-phase studies through pivotal trials, guiding clinical strategy, medical oversight, and regulatory interactions. This role offers the opportunity to shape programs in an innovative, fast-growing biotech environment.Key Responsibilities:Strategic LeadershipDefine and drive the overall clinical development strategy in alignment with corporate objectives.Serve as the clinical voice on the executive team, providing insight into trial design, regulatory engagement, and portfolio prioritization.Clinical Development ExecutionLead the design and implementation of clinical studies (Phase I-III), ensuring scientific rigor and regulatory compliance.Oversee medical monitoring, safety assessments, and data interpretation across programs.Partner with Clinical Operations, Regulatory, and Translational teams to advance programs efficiently.Regulatory & External EngagementAct as primary medical representative in interactions with regulatory authorities (FDA, EMA, etc.).Build and maintain strong relationships with KOLs, investigators, and external partners.Represent the company at major scientific and medical conferences.Team LeadershipRecruit, mentor, and manage a growing clinical development team.Foster a collaborative, high-performance culture across R&D and clinical functions.Qualifications:MD, MD/PhD, or equivalent with board certification in Oncology, Hematology, or a related specialty.10+ years of clinical development experience in the biopharma industry, including leadership of early- and late-phase oncology trials.Proven success in authoring INDs, IBs, and regulatory submissions; direct FDA/EMA interaction experience required.Track record of building and leading cross-functional teams in a fast-paced biotech or pharma setting.Deep understanding of immuno-oncology, cell therapy, or novel biologics preferred.Entrepreneurial mindset with the ability to thrive in a dynamic SME environment.Willingness and ability to work onsite in Cambridge, MA at least three days per weekWhat We Offer:Executive-level role with significant impact on the trajectory of a rapidly advancing pipeline.Competitive compensation package including equity participation.Opportunity to work on innovative science with the potential to transform patient outcomes.Collaborative, mission-driven culture in the heart of the Cambridge biotech ecosystem.Hybrid flexibility balanced with in-person collaboration: leaders are expected onsite at least three days per week.If you're interested in this role, please apply directly. If you have any questions please feel free to get in touch with me directly on:joel.isaac@

Created: 2025-09-25