Technical Project Manager

Technical Project Manager - Radiopharmaceutical ProgramOrchestra Life Sciences | Madison, WIAbout Orchestra Life SciencesOrchestra Life Sciences is a technical consultancy delivering deep expertise in nuclear medicine development, specializing in Radioligand Therapies (RLTs) and Targeted Alpha Therapies that are transforming cancer treatment. We provide end-to-end capital project solutions that take specialized facilities from feasibility studies through cGMP qualification, with a proven track record of optimizing regulatory compliance, costs, and timelines. Our team of subject matter experts brings more than 100 years of combined experience in novel therapies, working in concert with clients across nuclear medicine, radiation oncology, cell and gene therapies, regenerative medicines, and biotechnology to accelerate life-saving treatments to market.Position OverviewWe are seeking a Technical Project Managerto join our growing Radiopharmaceutical Program team, managing complex, multi-disciplinary projects at the forefront of nuclear medicine. This role offers a unique opportunity to drive delivery excellence across a portfolio of high-impact capital equipment projects"”including hot cells, cyclotrons, and large-scale process systems"”as well as process scale-up and commercialization initiatives. You will serve as the central coordinator and accountable owner of project execution, working closely with process engineers, mechanical engineers, automation specialists, quality teams, and clients to keep programs on scope, schedule, and budget. Your work will directly enable life-saving cancer therapies to reach patients.Work Environment & TravelThis is a hybrid positionoffering flexibility to work from home, our Madison office, and client project sites nationwide. Project phases require varying levels of face-to-face collaboration for effective delivery. Travel expectations typically range from 25-50%. Travel requirements may increase during critical project phases such as equipment procurement, Factory Acceptance Testing (FAT), commissioning activities, and startup operations. Travel is scheduled during business days to support project delivery; extended travel over weekends to enable consecutive weeks onsite is not typical practice.Key ResponsibilitiesProject Planning & Execution: Own end-to-end project delivery for capital equipment and process projects, including scope definition, integrated scheduling, resource planning, risk management, and budget trackingDevelop and maintain project plans, work breakdown structures (WBS), and critical path schedules for multi-disciplinary teams across engineering, procurement, construction, and qualification phasesDrive accountability across internal team members and external vendors, ensuring milestone commitments are met and issues are escalated with solutionsCapital Equipment & Facility Projects: Manage projects for large capital equipment including hot cells, cyclotrons, isolators, containment systems, and process skids from concept through commissioning and handoffCoordinate procurement, vendor management, and logistics for specialized radiopharmaceutical equipment, interfacing with hot cell suppliers (e.g., Comecer, Von Gahlen, PBL) and other OEM partnersSupport Factory Acceptance Testing (FAT), Site Acceptance Testing (SAT), and equipment qualification (IQ/OQ/PQ) activities, ensuring execution against approved protocols and documentation requirementsInterface with facility design teams, architects, construction partners, and client operations teams to ensure equipment and process requirements are aligned with building systems and site readinessProcess Scale-Up & Commercialization Projects: Lead project management for radiopharmaceutical process scale-up initiatives, from R&D through pilot and commercial manufacturing, coordinating cross-functional workstreams across process engineering, quality, and regulatory teamsTrack and report on critical process parameters, technology transfer milestones, and regulatory submission timelines, ensuring dependencies are visible and risks are proactively managedPartner with process engineers to develop project-level plans for process validation, equipment qualification, and operational readiness activitiesStakeholder Communication & Reporting: Serve as the primary point of contact for project status, maintaining clear and consistent communication with clients, internal leadership, and project team membersProduce weekly project health reports with clear status indicators (Green / Yellow / Red), risk registers, and action item logs; ensure no surprise escalationsFacilitate project meetings, design reviews, and coordination calls, driving clear decisions, documented action items, and accountabilitySupport proposal development and project scoping activities by providing realistic schedule and resource estimates grounded in project experienceRequired QualificationsBachelor's degree in a technical field, or equivalent work experience in mechanical engineering, chemical engineering, project engineering, or a related discipline7+ years of project management experience on complex, multi-disciplinary technical projects in biotech, pharma, life sciences, nuclear, or regulated manufacturing environmentsDemonstrated experience managing capital equipment projects, including vendor coordination, procurement, and installation oversightStrong understanding of project management fundamentals: scope management, scheduling (critical path), risk management, budget tracking, and change controlExperience developing and maintaining integrated project schedules using tools such as MS Project, Smartsheet, or equivalentExcellent communication and stakeholder management skills, with ability to translate technical complexity into clear updates for diverse audiencesComfortable working in a fast-paced, matrixed consulting environment across multiple active projects simultaneouslyPreferred QualificationsMechanical engineering background or project engineering experience in equipment design, procurement, or installationFamiliarity with GMP requirements, FDA regulations (21 CFR Parts 210/211), and pharmaceutical quality systemsExposure to radiopharmaceutical manufacturing, hot cell operations, or nuclear medicine production environmentsExperience on new facility construction or new production line startup projectsKnowledge of equipment qualification activities (IQ/OQ/PQ, FAT/SAT) and associated documentation requirementsPMP certification or equivalent project management credentialExperience working in a consulting or client-facing technical services environmentWhy Join Orchestra?Help build the infrastructure for next-generation cancer therapies that are transforming oncology treatmentIndustry Impact: Manage projects spanning capital equipment, process development, facility integration, and commercial scale-up across multiple clients and therapeutic modalitiesTechnical Variety: Serve as the accountable leader for project delivery"”your decisions and discipline directly shape client outcomesMeaningful Ownership: Work alongside industry-leading engineers, scientists, and consultants in a knowledge-sharing, high-trust environmentCollaborative Culture: Gain deep exposure to the emerging radiopharmaceutical sector at a company shaping the standards of the fieldProfessional Growth: Madison office with flexible arrangements; travel to client sites as neededLocation: Orchestra Life Sciences is an equal opportunity employer committed to building a diverse and inclusive team.

Created: 2026-05-16