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Scientist - Lung Organoid Models

Pharmaceutical Company - South San Francisco, CA

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Job Description

We are seeking a highly motivated Scientist to join the Complex In Vitro Systems (CiS) Lab within Translational Safety. This role will focus on developing and characterizing advanced human lung in vitro models to support drug discovery, translational research, and safety assessment initiatives.The ideal candidate will have strong experience with lung organoids, air-liquid interface (ALI) cultures, co-culture systems, and complex in vitro disease models. This is a highly collaborative, lab-based role working closely with cross-functional research and development teams.Responsibilities:Develop and characterize advanced lung in vitro models including airway/alveolar organoids and ALI culturesDesign and execute experiments involving imaging, transcriptomics, and functional assaysPerform cell culture, assay optimization, and model qualification studiesAnalyze and interpret complex biological datasetsMaintain high-quality scientific documentation and contribute to presentations/reportsCollaborate with translational research, safety, and drug development teamsQualifications:PhD in Bioengineering, Cell Biology, Molecular Biology, Toxicology, or related field0-5 years of post-PhD experience in academia or industryHands-on experience with lung cell culture and organoid systemsStrong experience with confocal microscopy, immunofluorescence, qPCR, RNA-seq, or high-content imagingExperience with microphysiological systems or organ-on-chip platforms is highly preferredStrong communication, troubleshooting, and experimental design skillsPreferred:Lung biology or immunology experienceMATLAB and/or Python experience for image/data analysis

Created: 2026-05-16

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