Sr. Manager, Bioinformatics Operations (Hybrid - San ...

Sr. Manager, Bioinformatics Operations (Hybrid - San Juan Capistrano, CA)Salary: $140,000-$170,000 + BonusSchedule: Hybrid (3 days onsite/week)Location: San Juan Capistrano, CAOverview:We're seeking a Sr. Manager to lead Bioinformatics Operations in a clinical genomics lab environment. This role focuses on managing production-grade bioinformatics pipelines, ensuring operational excellence, and supporting both on-prem and AWS cloud infrastructure.Key Responsibilities:Lead and mentor a team of 5-7 bioinformatics professionals.Oversee daily operations, ensuring sample throughput and turnaround time (TAT) targets are met.Manage and troubleshoot bioinformatics pipelines (Nextflow, Snakemake).Support systems in both on-prem and AWS cloud environments.Ensure compliance with CAP, CLIA, ISO, FDA standards.Collaborate cross-functionally with lab scientists, IT, and engineering teams.Drive CI/CD adoption and maintain data integrity and secure archival.Must-Have Qualifications:7+ years in bioinformatics, software engineering, or related field.Hands-on experience with Python, R, Shell scripting, SQLStrong knowledge of AWS, CI/CD, and version control (Git).Experience with NGS workflows, variant calling, and sequence alignment.Proven leadership in regulated environments (CAP, CLIA, HIPAA, FDA)Excellent communication and stakeholder management skills.Preferred:MSc or PhD in Bioinformatics, Computer Science, or related field.Experience with LIMS, variant interpretation platforms.Agile certification.Salary offers are based on a wide range of factors, including relevant skills, training, experience, education, and, where applicable, certifications obtained. Market and organizational factors are also considered. Successful candidates may be eligible to receive annual performance bonus compensation.

Created: 2025-10-02