Responsibilities Neonatal Intensive Care RNs (NICU RNs) assess newborns and provide direct and individualized care. NICU RNs coordinate with the healthcare team to implement and evaluate patient care plans. NICU RN job responsibilities include, but are not limited to: Administer medications and nutrients to patients and monitor vital signs Provide respiratory care if applicable and specialized feedings Monitor specialized equipment used on patients, such as incubators and ventilators