Sr Research Associate Mammalian Cell Culture - Process ...

Job DescriptionThe client mission is to create a newgeneration of smarter medicines that outmaneuver complex diseases in wayspreviously inconceivable. They are passionate about designing gene circuits toimprove the "intelligence" of cell and gene therapies in order to enhance theirtherapeutic effectiveness against a broad range of diseases that conventionalmedicines are unable to address. The client find purpose and meaningknowing that their efforts have the potential to improve the lives of patientsand their families with more effective and safer treatment options. Withscience as our foundation and empathy as their key guiding principle, colleaguesbecome friends, managers become mentors, and with time, cancer becomes history. They are seeking anenthusiastic, self-driven Research Associate to join its Process Science teamthat is focused on advancing new products and enabling technologies. Thisrole will be part of a team of associates and scientists that develop processesand technologies for manufacturing NK-cell therapies. The position willrequire experimental design, experimental execution, troubleshooting andoptimization of processes, data analysis, drafting of and presentation of results.Responsibilities Contribute to process development for cell therapy development programs, including natural killer (NK cells) and other therapeutic cell modalities. Perform small- and large-scale experiments using primary cells to support multiple operations including expansion, gene editing, selection/expansion of clones, cell harvest, and cryopreservation. Perform transductions on primary human cells via viral vectors and other genes delivery methods. Supports process optimization efforts to increase process robustness, improve transduction efficiency, cell yield and purity. Contribute to donor screening and testing processes using high-throughput assays. Collaborate with research teams on relevant ex-vivo assays (Flow Cytometry, ELISA, Luminex-based assays and PCR). Helps design and execute experiments with great attention to detail. Maintain accurate lab records and notebooks. Author protocols, reports, and standard operating procedure documents. Present results in team meetings and delivers presentations to both small and large groupsQualificationsBachelor''sor Master''s degree in Cell & Molecular Biology or related life sciencefield, with a minimum of 2 years of experience, preferably in a processdevelopment settingExperiencewith mammalian tissue culture including both adherent and suspension cells.Proficiencywith flow cytometry strongly preferred.Abilityto design and execute experiments with minimal technical supervision.Ability to multitask and meet deadlines in a fast-paced environment.Highly organized and detailed oriented individual with strong troubleshooting andproblem-solving skills.Mustbe a team player, proactive, and willing to work in a small team environment.Musthave excellent verbal and written communication skills.Proficientwith MS Office and other commonly used software and technology platforms.Self-motivated andeager to take on temporary responsibilities outside of the initial job descriptionBenefitsThe client is a leading gene circuit company designing gene circuits to create a new generation of "smartermedicines'' and enhance the therapeutic effectiveness of cell and genetherapies against a broad range of diseases that are unaddressed by currentstandards of care. We are proud to count Leaps by Bayer, NEA, 8VC, MatrixPartners China, Mirae Asset Capital, Amgen Ventures, Intel Capital, RidgebackCapital, Lux Capital, KB Investment, Pear VC, Smilegate Investment, MenloVentures, LifeSci Venture Partners, Alexandria Venture Investments, Allen & The company, LifeForce Capital, Omega Funds, Nest.Bio, Gaingels, Noveus Capital,and Goodman Capital among our investors and company is based in South SanFrancisco, CA, USA.Base pay and stock options are to be determined based on applicant qualifications with the aim of being competitive with similar roles in the area.Significant growth opportunity as the company expands

Created: 2021-11-29