Senior Scientist, Systems Biology

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I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Systems Biology Senior Scientist will be part of a team focused on bioinformatics and computational biology support of translational pre-clinical data analysis supporting the neuroscience therapeutic area.The goal is to apply expertise in bioinformatics, genomics, machine learning and computational biology to integrate and analyze pre-clinical and clinical, internal and public molecular profiling 'omics datasets to support Takeda translational and clinical projects in neuroscience therapeutic area.To independently design, develop and execute research assignments, contributing to multiple projects, acting as senior scientific consultant or as manager of a smaller, early staged matrix project team.To drive collaborations with internal groups, external partners, including CROs and academia for data analysis and machine learning.Join Takeda as a Senior Scientist in our Systems Biology team, based in Cambridge, MA.How you will contribute:ACCOUNTABILITIESSupport neuroscience clinical science and translational research teams to achieve translational research and clinical objectives using advanced computational biology and bioinformatic approaches.Generate and evaluate hypotheses for patients'' stratification, target validation, drug mechanism, and indication prioritization efforts from big 'omics data.Curate and harmonize big 'omics publicly available resources.Identify, build, and use bioinformatic pipelines to QC omics data types including genomics, transcriptomics and proteomics to extract novel and biologically meaningful information.Apply various computational biology methods for translational research, including systems biology, pathway/network analysis, such as, GWAS, pheWAS, PGS, teract closely with biologists and clinicians to conduct analyses, data integration and data terpret preclinical and clinical datasets using appropriate computational and statistical methods.Create visualizations, interpret high dimensional data and explain results to cross-functional teams.Schedule and execute tasks to meet deadlines.Plan and coordinate computational biology activities internally and in partnership with external CROs and academic partners, including complex projects requiring collaboration with multiple members of the team and organizations.Prepare and present comprehensive scientific reports to a full range of internal and external audiences.Work collaboratively with data scientists and data engineering groups to enhance our computational infrastructure, user interface, query, and visualization capabilities.Writes study reports and presents data effectively in all settings and with participants of all levels of the organization.DIMENSIONS AND ASPECTS Demonstrates in-depth knowledge of currently assigned research methodsUnderstands the basics of oligonucleotide synthesisDemonstrates basic knowledge of science/technology outside specific disciplineRecognizes problems and considers the significance of irregularitiesTechnical/Functional (Line) Expertise Solid background in genetics and genomics with an understanding of neurological disorders, and ability to interpret genetic and genomic findings in disease context.Strong background with high dimensional data analysis derived from Next Generation Sequencing, including: RNASeq, DNASeq, epigenetics, and single cell sequencing.Solid hands-on experience with GWAS/PheWAS/eQTL/pQTL analyses, WES/WGS sequencing data analyses, and rare variants analyses required.Experience in using pathway-based approaches, multivariate analyses, polygenic risk score analyses, machine learningHands on experience in using public big 'omic human databasesKnowledge of and experience with bioinformatic techniques.Hands-on experience developing and implementing bioinformatic pipelines for data analysis of RNASeq, DNASeq, proteomic and longitudinal phenotypic data.Solid knowledge of Unix/Linux, command line interfaces, and fluency in some common scripting and/or programming language (e.g., R, Python, Perl, Java, C / C++).Familiarity with parallel computing, relational databases (e.g., SQL) and cloud computing or distributed computing (i.e., AWS).Theoretical knowledge of bioinformatics, computational biology; keeps current with emerging trends in bioinformatics and computational biology.Familiarity with popular public domain data sources and programmatic interfaces.Experience in designing and conducting computational biology activities to meet program objectives; able to provide input on timelines and resource needs as indicated.Able to evaluate/develop computational methods based on project needs.Excellent problem solving, communication, presentation, and interpersonal dependent, self-starting and supportive of team-based research and able to work effectively in a matrix organization.Background in/experience with Neuroscience is a plusMinimum Requirements/Qualifications:PhD degree in a scientific discipline, with 3+ years'' experience, orMS with 9+ years'' experience, orBS with 11+ years'' experiencePrevious industry experience, preferably with big pharmaceutical companies and on clinical programs.What Takeda can offer you:Comprehensive Healthcare: Medical, Dental, and VisionFinancial Planning & Stability: 401(k) with company match and Annual Retirement Contribution PlanHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach Programs and company match of charitable contributionsFamily Planning SupportFlexible Work PathsTuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Created: 2025-10-04