Senior Scientist-Circuits and Engagers

Senior Scientist-Circuits and EngagersGaithersburg, MDThis OpportunityThe Early ICC Discovery Oncology team at AstraZeneca in Gaithersburg, MD is seeking a highly motivated Senior Scientist with a proven track record in histology and immunohistochemistry (IHC). The ideal candidate will work independently and in collaboration with others to conduct scientific research as part of a team effort. This role will be responsible for the development of IHC/IF and ISH methods, tissue sectioning, and other histological techniques, as well as perform basic flow cytometry, cell culture, western blot activities as needed. The Senior Scientist in this cross-functional role, will participate in project teams and work in a multidisciplinary environment in order to advance projects.Education Requirements: * PhD degree in immunology, immuno-oncology or other relevant area of research * Ideal candidate should have a background in research and some exposure to immunohistochemistry and immunofluorescent staining, antibody validation, flow cytometry, tissue culture, drug target validation.Typical Accountabilities: * Works closely with team in the development of IHC/IF and ISH assays in support of early target discovery. Share results to team members. * Assesses and reports data in a clear and concise manner, while understanding the implications to the overall context of drug discovery. * When appropriate shares relevant external published papers with peers. * Will perform microtomy sectioning for the early oncology team. * Will be responsible for routine maintenance and troubleshooting of laboratory equipment. * Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulationsEssential Skills: * The position is a hands-on, primarily laboratory based position. * Responsible for the application of immunohistochemistry principles and techniques to help validate new targets. * Prepares precise technical summaries, protocols and all appropriate documentation of experiments in laboratory notebooks. May contribute to preparation of manuscripts and/or patent applications. * Able to make detailed observations, analyze data and interpret results, with potential for presenting findings at internal meetings. * Provides solutions to a variety of problems involving basic scientific principles. * Responsible for the correct operation and utilization of lab equipment, and overall state of the shared lab space. * Willingness to learn new technologies and techniques as they relate to project needs. * Responsible for establishing working relationships and credibility with department members and others within the company. * Design and perform experiments, interpret results and subsequently plan new experiments to move a project forward. * Possess excellent oral and written communication skills. * Ability to prioritize and work in a fast-paced, matrixed environment is required. Desired Skills: * Have a desire to learn basic human tissue histology and identification of basic elements of tissue under the microscope. * Familiar with the use and application of Westerns and flow cytometry as they pertain to the validation of commercial antibodies and drug targets. * Familiar with digitization of histology slides and have some basic knowledge of automated image analysis. * Have some experience with handling and management of human tissue specimens, including development and maintenance of sample tracking systems. * Have understanding common techniques and methods used in tissue culture. Closing Date: September 9, 2022Competitive remuneration and benefits applyWe offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Start date: ASAPSkills: Immunology, Drug Discovery, Immunohistochemistry, PhDSalary: Negotiable This employer is a corporate member of myGwork - LGBTQ+ professionals, the business community for LGBTQ+ professionals, students, inclusive employers & anyone who believes in workplace equality.

Created: 2025-10-04