Sr. Research Associate II - Neuroscience Histology/Ex ...

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda''s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Sr. Research Associate II will independently contribute to the development of neuroscience-relevant biomarker assays and provide histology support to portfolio programs within the Neuroscience Drug Discovery Unit. This includes; preparation of rodent brain tissue for histology, immunohistochemistry, immunofluorescence, in situ hybridization/RNAscope and other methods to evaluate biological targets in brain tissue, confocal microscopy and quantitative analysis (manual or automated). Expertise in ex vivo assays such as western blot, ELISA, PCR a plus. This position requires agility and flexibility to switch between independent work and collaboration with a high-performing close knit team. The ideal candidate will provide complex problem resolution within project scope.Join Takeda as a Sr. Research Associate II - Neuroscience Histology/Ex Vivo Biomarker, based in San Diego, CA.How you will contribute:ACCOUNTABILITIESWorks independently to conduct multiple complex analyses of biological targets in brain tissue, requiring preparation and sectioning of brain tissue via cryostat or other methods, immunohistochemistry/immunofluorescence or other histology methods, microscopy, quantitative assessment (manual and/or automated).Independently follows protocols, develops and validates novel protocols/assays, and troubleshoots non-routine methods, instrumentation and software issues.Expected to be highly organized, able to manage priorities and set appropriate weekly workload for the ex vivo studies including coordinating with project leaders to set acceptable timelines for each project based on urgency and resource municate clearly with a variety of partners including in vivo pharmacology team and other neuroscientists; works collaboratively when required on study design and assay development. Prepares and presents technical information and data updates at project or departmental meetings as appropriateIndependently keeps abreast of current Neuroscience literature to increase knowledge base and implement improvementsKeeps an accurate, comprehensible, concise notebook in accordance with company policyPerform general lab support duties including preparation of solutions and ordering supplies.Able to train junior personnel to perform studiesMinimum Requirements/Qualifications:BS in a scientific discipline (or equivalent) with 6+ years experience, or MS in a scientific discipline, or equivalent with 2+ years experienceExpertise in rodent brain tissue preparation and use of cryostat/vibratome/microtome required. Experience with human or non-human primate brain tissues desirable.Expertise in immunohistochemistry/immunofluorescence and other histological methods requiredExperienced in evaluating antibodies and developing PCR probesExpertise in confocal or other microscopyUtilizes a battery of ex vivo assay technologies; qPCR, western blot, immunoassays or other ex vivo tissue analysis methods Experience in immunoprecipitation and protein extractionHighly skilled in quantitative analysis of targets in brain tissue, statistical analysis, graphing programs like Graphpad Prism, PowerPoint presentations, Excel and software programs to image tissues and analyze histological targetsFamiliarity with rodent in vivo methods (i.e. handling, p.o.dosing), necropsy and sample collection procedures a plusExcellent written and verbal communication skills and possess the ability to work independently as well as part of a tightknit teamExperience in drug discovery, particularly Neuroscience and diseases of the central nervous systemAbility to mentor junior scientists and internsAbility to design and interpret experiments collaboratively and independentlyAbility to be agile and flexible- manage multiple tasks and priorities to achieve desired goalsExcellent attention to detailWhat Takeda can offer you:Comprehensive Healthcare: Medical, Dental, and VisionFinancial Planning & Stability: 401(k) with company match and Annual Retirement Contribution PlanHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach Programs and company match of charitable contributionsFamily Planning SupportFlexible Work PathsTuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsSan Diego, CAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Created: 2025-10-04