Staff Engineer/Scientist ADC and Purification Process ...

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda''s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAt Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as a Staff Engineer/Scientist ADC and Purification Process Development where you will be empowered to design and develop conjugation and purification processes for ADCs and transfer these processes to manufacturing. You will also manage the development and optimization of manufacturing processes for ADC pipeline compounds. As part of the Process Development team, you will report to Director, Process Development.How you will contribute:Manage the development and optimization of manufacturing processes for ADC pipeline compounds including conjugation and purification. Additionally, will support purification process development for other biologics.Ensure that processes developed are amenable to transfer to a manufacturing site including potential contract manufacturers.Design and oversee activities to support scale-up of both ADC conjugation and purification processes.Provide on-site presence to support technology transfer and manufacturing.Working with associated analytical colleagues, develop phase appropriate control strategies to support GLP/GMP manufacturing efforts.Produce and review development reports for work performed.Present scientific presentations both internally and externally.Some of the work will involve handling of high-potency compounds in a containment facility and isolators. Use respirator and personnel protection equipment may be required.Mentor junior colleagues in each of the above aspects of process development.Minimum Requirements/Qualifications:A PhD in Chemical/Biochemical Engineering with 0+ years of relevant industry experience or a MS in Chemical/Biochemical Engineering with 5+ relevant industry experience or a BS in Chemical/Biochemical Engineering with 8+ relevant industry experience required.Experience working with proteins.Experience working with small molecules is a plus.Experience with protein purification methods including UFDF, TFF, and preparative chromatography, including AKTA instruments and Unicorn software.Prior experience with protein conjugation and purification techniques is required. Experience with a broad variety of conjugation schemes (e.g. conventional, multiple site-specific, enzymatic) is preferred.Experience with high-potency compounds including safe handling.Knowledge of Process Development including requirements for successful regulatory description of manufacturing processes.Experience with GxP/GMP production.Experience with design of experiments, experience with JMP preferred.Familiarity with Quality by Design, late-stage process development, and process characterization preferred.Experience with analytical instrumentation, particularly HPLC.Demonstrated capability to learn quickly, and an ability to multi-task within a dynamic environment with changing priorities/directions.Ability to meet timelines.What Takeda can offer you:Comprehensive Healthcare: Medical, Dental, and VisionFinancial Planning & Stability: 401(k) with company match and Annual Retirement Contribution PlanHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach Programs and company match of charitable contributionsFamily Planning SupportFlexible Work PathsTuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.This position is currently classified as ''hybrid'' in accordance with Takeda''s Hybrid and Remote Work accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.LI-SB1EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsLexington, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Created: 2026-03-07