Principal Scientist-DMPK- Oncology

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda''s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:Our vision is to be a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients.Join Takeda as a Principal Scientist where you will (lead DMPK support across our rich oncology drug discovery and development portfolio.. As part of the DMPK team, you will report to Director Haiqing Wang.How you will contribute:Represent DMPK in multifunctional discovery and development oncology project teams. Engage with Biology, Medicinal Chemistry, Toxicology, Regulatory, and Clinical departments to implement DMPK strategies to improve and characterize candidate properties for clinical advancement.Lead PK, PK/PD, and ADME studies. Identify issues and help overcome experimental challenges; Responsible for quantitative data analysis and interpretation to characterize therapeutics exposure and safety/efficacy relationship.Author high-quality regulatory documents including ADME/DMPK sections of IND/IB. Contribute to review of regulatory documents.Play a visible role in global DMPK community to share learning and enhance consistency in best practices across sites and disease areasMinimum Requirements/Qualifications:Ph. D. degree in pharmacokinetics, pharmaceutical sciences, or related disciplines.Minimum 8 years of pharmaceutical industry with small molecule and biologics experience. Experience in gene and cell therapies.5+ years of experience with pharmacokinetics, drug metabolism, pharmacodynamic and bioanalytical principles is requiredPK/PD analysis skills and mathematic modeling skill, with experience in modeling software, such as WinNonlin, ADAPT, NONMEM, or MATLAB.What Takeda can offer you:Comprehensive Healthcare: Medical, Dental, and VisionFinancial Planning & Stability: 401(k) with company match and Annual Retirement Contribution PlanHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach Programs and company match of charitable contributionsFamily Planning SupportFlexible Work PathsTuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Created: 2025-11-15