Principal Scientist, Neuroscience

This range is provided by GondolaBio. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.Base pay range$190,000.00/yr - $205,000.00/yrCompany Background:GondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Originally launched as BridgeBioX, a subsidiary of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. The company aims to leverage cutting-edge biological research to create breakthrough medicines addressing high unmet needs across multiple therapeutic areas, including neurology, pulmonology, cardiology, nephrology, and endocrinology. Located on the Stanford Life Sciences campus, GondolaBio fosters a unique hybrid environment where top scientists from around the world collaborate with senior leadership and advisors, blending industry expertise with academic innovation.Who You Are:We're seeking an entrepreneurial scientific leader who combines intellectual rigor with practical execution skills to advance our Neuroscience pipeline at GondolaBio. You will serve as the scientific lead for multiple preclinical neuroscience programs. You will play a pivotal role in designing, executing, and interpreting experiments. This position offers the opportunity to shape research strategy while mentoring junior scientists and contributing to a growing, interdisciplinary team.Responsibilities:Lead the design and execution of in vitro studies across multiple preclinical discovery programs in neurodevelopmental disordersDevelop and optimize functional assays and neuronal models (e.g., iPSC-derived and primary cultures) to support SAR, MoA, target engagement, and efficacy assessmentsPerform and interpret molecular, protein, and functional analyses (e.g., qPCR, Western blot, MEA), integrating findings with in vivo and translational dataSupervise and mentor junior scientists, fostering a high-performing and collaborative research environmentOversee external research activities, including CRO and academic collaborations, ensuring high-quality and timely data deliveryStay abreast of emerging science, engage with external experts, and represent the company at scientific meetingsCommunicate results and strategic insights to senior leadership; contribute to publications and IPPartner with leadership to shape and execute a cohesive research strategy that advances program objectives across discovery and translational stagesEducation, Experience & Skills Requirements:PhD in Neuroscience or a related field with 4+ years of industry experience; strong publication record is a plusTherapeutic domain expertise in neurological diseases and experience with in vivo CNS disease models; experience in neurodevelopmental disorders is a plusExtensive experience with human iPSC-derived neuronal models and neurobiology-focused assay developmentProficiency in qPCR, Western blot, MEA, and neuronal culture techniquesSound knowledge of disciplines involved in drug discovery (cell-based disease models, target engagement and target modulation assays, cell viability assays, biomarker discovery, PD/PK, and efficacy studies) and experience with small molecules, plate-based cellular and biochemical assays; experience with antisense oligonucleotides a plusDemonstrated ability to manage projects and lead junior team membersStrong problem-solving, communication, and cross-functional collaboration skillsExperience in biotech or pharmaceutical R&D preferredNo matter your role at GondolaBio, successful team members are:Patient Champions, who put patients first and uphold strict ethical standardsEntrepreneurial Operators, who drive toward practical solutions and have an ownership mindsetTruth Seekers, who are detailed, rational, and humble problem solversIndividuals Who Inspire Excellence in themselves and those around themHigh-quality executors, who execute against goals and milestones with quality, precision, and speedWhat We Offer:Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our effortsA culture inspired by our values: put patients first; think independently; be radically transparent; every minute counts; and let the science speakCollaborative business environmentExcellent compensation package (Base, Performance Bonus, Equity)Excellent benefits packageFlexible PTOA fast-paced, data-driven, work environment with world-class R&D minds and capabilitiesWork with the most productive groups of R&D operators in the industryA platform for meaningful scientific contributions to shineSeniority levelSeniority levelExecutiveEmployment typeEmployment typeFull-timeJob functionJob functionScienceReferrals increase your chances of interviewing at GondolaBio by 2xSan Francisco, CA $139,000 - $186,000 4 weeks agoPrincipal/Senior Scientist, Analytical ScienceSenior Staff Scientist, Computational ChemistryRESEARCH SCIENTIST SUPERVISOR I (CHEMICAL SCIENCES)Principal Scientist – Biomarker Development and Translational ResearchTechnical Development Principal ScientistResearch Scientist, Design and SimulationPrincipal Scientist, Small Molecule Analytical SciencesResearch Scientist Manager - 3D Generative AISan Francisco, CA $136,000 - $212,800 21 hours agoSenior Scientist, Formulation Fill/FinishBrisbane, CA $160,164 - $213,972 1 week agoSenior Clinical Scientist (Ophthalmology)We’re unlocking community knowledge in a new way. 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Created: 2025-09-17