Principal Scientist, ASO Biologist

OverviewJoin to apply for the Principal Scientist, ASO Biologist role at GondolaBioGondolaBio is a clinical-stage biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. Located on the Stanford Life Sciences campus, GondolaBio fosters a hybrid environment where scientists collaborate with senior leadership and advisors to blend industry expertise with academic innovation.Who you areWe're seeking an entrepreneurial scientific leader who combines intellectual rigor with practical execution skills to advance our antisense oligonucleotide (ASO) pipeline at GondolaBio. You will serve as a scientific lead for multiple preclinical ASO programs in collaboration with the n-Lorem foundation. You will design, execute, and interpret experiments, shape research strategy, and mentor junior scientists within a growing, interdisciplinary team.ResponsibilitiesServe as a subject matter expert for ASO discovery, design, and preclinical evaluation across multiple programsLead the design and execution of in vitro studies across multiple preclinical programs using the ASO modalityDevelop and optimize functional assays and disease models (e.g., iPSC-derived and patient primary cell-derived) to support target engagement and efficacy assessmentsPerform and interpret molecular, protein, and functional analyses (e.g., qPCR, Western blot), integrating findings with in vivo and translational dataDesign and interpret in vivo efficacy, safety, and target engagement experiments for ASOs in multiple indicationsSupervise and mentor junior scientists, fostering a high-performing and collaborative research environmentOversee external research activities, including CRO and academic collaborations, ensuring high-quality and timely data deliveryStay abreast of emerging science, engage with external experts, and represent the company at scientific meetingsCommunicate results and strategic insights to senior leadership; contribute to publications and IPPartner with leadership to shape and execute a cohesive research strategy that advances program objectives across discovery and translational stagesEducation, Experience, & SkillsPhD in chemistry, biology, or a related field with 4+ years of industry experience; strong publication record is a plusModality expertise in ASOs and experience with preclinical discovery, design, and testing of ASO efficacy and safetyExperience with in vitro and in vivo disease models across multiple therapeutic areas (neuroscience and renal experience is a plus)Proficiency in preclinical ASO experiments, including qPCR, Western blot, iPSC and patient primary cell cultureSound knowledge of disciplines involved in drug discovery (cell-based disease models, target engagement and target modulation assays, cell viability assays, biomarker discovery, PD/PK, and efficacy studies) and experience with plate-based cellular and biochemical assaysDemonstrated ability to manage projects and lead junior team membersStrong problem-solving, communication, and cross-functional collaboration skillsExperience in biotech or pharmaceutical R&D preferredNo matter your role at GondolaBio, successful team members arePatient Champions, who put patients first and uphold strict ethical standardsEntrepreneurial Operators, who drive toward practical solutions and have an ownership mindsetTruth Seekers, who are detailed, rational, and humble problem solversIndividuals Who Inspire Excellence in themselves and those around themHigh-quality executors, who execute against goals and milestones with quality, precision, and speedWhat We OfferPatient Days, where we hear directly from individuals living with the conditions we are seeking to impact and learn how we can improve our effortsA culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speakAn unyielding commitment to always putting patients firstA decentralized model that enables program teams to focus on advancing science and helping patientsA place where you own the vision – both for your program and your own career pathA collaborative, fast-paced, data-driven environment with high performance expectationsAccess to learning and development resources to support professional growthRobust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)Flexible PTORapid career advancement for strong performersPotential to work on multiple GondolaBio programs across therapeutic areas over timePartnerships with leading institutionsCommitment to Diversity, Equity & InclusionCompensationThe base pay range for this position is $190,000 to $205,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.Seniority levelMid-Senior levelEmployment typeFull-timeJob functionScienceWe’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. #J-18808-Ljbffr

Created: 2025-09-17