Staff Bioinformatics Scientist

OverviewGuardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.Job DescriptionThe position is in the bioinformatics group and will work on the development of computational models for both the screening products (Shield) and the oncology products (e.g., Guardant360). The major responsibilities are to:ResponsibilitiesDevelop, prototype, and analyze performance of novel statistical/machine learning models to further improve early cancer detection, minimal residual disease detection, longitudinal monitoring of treatment response, and cancer-signal predictionWork closely with other teams to develop new technologies, through hands-on work and providing ideas to team membersIdentify relevant external genomic, epigenomic and proteomic data sources and integrate with internal data to improve product performance and suggest new product featuresParticipate in brainstorming sessions, maintain a highly productive and motivating work environmentWork cross functionally with other teams to provide insight and feedback on projectsProvide written documentation and specifications for transparency and reproducibilityThe location for this position is either Palo Alto or San Diego.QualificationsDedicated to make a difference in a rapid-paced, collaborative startup-like environmentPh.D. in computational biology/bioinformatics, genomics, machine learning, or related field and a minimum of 8+ years related experienceExperienced with statistical models for genomic/epigenomic dataProficiency with high-level scripting (Python/R; Python)Experienced in visualization of complex experiments to derive biological insightsProficiency creating interactive tools and dashboards (streamlit, CLI tools, etc.)Proficiency creating and maintaining large data lakes and automated processing of constantly incoming dataCancer biology and/or epigenetics backgroundExperience in analyzing public genomic/epigenomic datasets (e.g. TCGA, ENCODE)Proficiency with Linux command-line and version control tools (git and GitHub)Ability to build reproducible and well written code (or packages) for data analysisFamiliar with high-performance computing infrastructures (e.g., SGE, AWS, Spark)Additional InformationHybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.The US base salary range for this full-time position is $148,500 to $204,210. The range does not include benefits, and if applicable, bonus, commission, or equity.For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $174,700 to $240,250. The range does not include benefits, and if applicable, bonus, commission, or equity.Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above.Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held beliefs. If you need support, please reach out to Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, disability, veteran status and will not be discriminated against on the basis of protected characteristics.All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants. Please visit our career page at: /jobs/ #J-18808-Ljbffr

Created: 2025-09-17