Scientist II Research and Development

Job DescriptionSource One is a consulting services company and we’re currently looking for the following individual to work as a consultant with our direct client, a global pharmaceutical manufacturing client in La Jolla, CA.This role will be onsite and available to candidates local to the La Jolla, CA area. We are interested in every qualified candidate who is eligible to work in the United States. Unfortunately, we are not able to sponsor visas or employ corp-to-corpTitle: Scientist II Research & Development (Oligonucleotide Analytics)Location: La Jolla, CAOnsite: Mon-Fri, 40 hoursContract Duration: 12 months, with likely extensionPay Rate: $52.26 per hour (w2)Key ResponsibilitiesOperating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects (30%)Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis (20%)Analyze and optimize methods in a project-specific way (e.g., GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS (10%)Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput (20%)Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography (5%)Continue optimizing siRNAs using best-in-class analytical chemistry methodologies such as different column matrices for optimal siRNA characterizationSupport integrity confirmation requests (such as concentration) by assay development and biology teamsConduct QC for lipid nanoparticle (LNP) formulations of mRNA (3%)Ensure the supply of laboratory consumables and reagents are in stock as neededMaintain a high level of productivity in the laboratory setting.Present data and reports on project status at individual, group, and departmental meetings (2%)QualificationsPh.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilitiesRole is 100% onsite #J-18808-Ljbffr

Created: 2025-09-17