Postdoctoral Researcher, Gilbert Lab

The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Arc is headquartered in Palo Alto, California and operates in partnership with Stanford University, UCSF, and UC Berkeley. Arc supports Core Investigators’ research by funding, technology development, operational and scientific support, and a culture that emphasizes curiosity, truth, collaboration, and long-term high-risk, high-reward science that aims to advance cures for diseases such as neurodegeneration, cancer, and immune dysfunction. Arc has scaled to more than 200 people, with $650M+ in committed funding and a state-of-the-art new lab facility in Palo Alto, and will continue to grow quickly. About the position The Gilbert Lab focuses on synthetic biology, functional genomics, and epigenetics, including using CRISPR approaches to control transcription. Our work addresses big problems in human biology, such as how cellular identity and the epigenome are determined and maintained, and how epigenetics and synthetic biology can inform new therapeutic strategies in cancer, viral biology, and neurodegeneration. The questions we ask include: How are genes turned on and off? How are mechanisms of epigenetic memory established and maintained? Which genes drive complex disease phenotypes and what are their mechanisms? How can we modulate these for therapeutic means? How can we use synthetic biology approaches to discover therapeutic strategies and design new gene, protein and small molecule therapeutics? How can we deliver genetic medicines to the right cell types in the body? Our approach includes CRISPR screens, high-throughput synthetic biology, perturb-seq, and in vitro disease models (including iPSC models and primary cells) as well as in vivo disease models. Post-docs will be encouraged to lead independent projects resulting in high-impact publications, present at conferences, and prepare for long-term careers in academia or industry. About you You are extremely curious and self-motivated to push the boundaries of biotechnology and/or biomedical research. You thrive in a fast-paced environment while conducting rigorous and impactful research. You are intellectually independent and can design new research directions and projects (with input from your PI). You are eager to learn and adapt new techniques. You are motivated by solving translational problems and by creating new therapeutic approaches. In this position you will Design, perform and analyze experiments Keep appropriate experimental records and documentation Analyze results with the Principal Investigator Perform general lab maintenance and operate/maintain equipment and instruments Collaborate with post-docs, students and staff May mentor/train research associates, technicians, and students Publish, present, and represent the lab in journals and conferences Present at lab meetings and participate in Arc-wide activities (seminars, symposiums, etc.) Requirements Doctorate (MD, PhD, VMD, or DDS) in a field related to the research specialization Excellent written and verbal communication skills Ability to work in a fast-paced environment and be an independent thinker and collaborative team player The minimum base salary for this position is $80,000. Base salary is determined by the number of months of relevant postdoctoral experience and is not negotiable. Apply for this job Interested candidates should provide a resume or CV and any other required materials through the official Arc Institute job portal. Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the voluntary self-identification survey. Completion is voluntary and will not affect hiring decisions. Any information provided is confidential. Arc Institute is an equal opportunity employer and does not discriminate on the basis of protected status. The information collected is for compliance with EEO and OFCCP requirements and does not affect the hiring decision. #J-18808-Ljbffr

Created: 2025-09-21