Formulation Senior Scientist

Senior Scientist, Formulation DevelopmentYour Impact at Syntis Bio: We are seeking a Senior Scientist to develop and optimize solid oral dosage forms for a platform technology for improved treatment of several therapeutic indications. The Senior Scientist will develop formulation-function relationships to allow for formulation optimization. In addition, this Senior Scientist will work with the regulatory, in vivo, and clinical teams, as well as external partners. The role will involve clearly presenting technical information to both a technical audience and non-technical audience. The role is on-site and located in Dorchester in Boston, MA.ResponsibilitiesLead development of formulations with Syntis Bio’s SYNT technology which incorporates a mucoadhesive polymer for treatment of multiple indications.Propose new formulation strategies for optimal performance, production, and stability particularly for drugs with poor oral bioavailability.Develop deep understanding of how formulation affects various aspects of function such as dissolution and permeability through optimization of in vitro characterization assays, ex vivo tissue-based assays, and in vivo animal studies.Support CMC sections of regulatory filings including INDs, BLAs, and terpret, analyze, present, and properly record data.Proactively seek opportunities to enhance our SYNT technology and other platforms through cross-functional collaboration with our internal and external research teams.Stay at the forefront of formulation innovations, proactively incorporating emerging tools and technologies to enhance team capabilities.Prepare documents and presentations that encompass project progression.Perform job related duties as assigned.The Ideal Skills:PhD in bioengineering, materials science, formulation sciences, pharmaceutical sciences, chemical engineering or equivalent relative experience and a minimum of 5+ years of industry experience.Understanding of polymer chemistry as it pertains to coating in solid dosage forms.Excited by and scientifically driven to overcome complex technical challenges that are impacted by multiple drug delivery factors.Deep experience with the development of solid oral dosage forms and the unit operations for production.Experience with the development of strategies to improve the oral bioavailability of molecules with low permeability (Ex. BCS Class III/IV, peptides).Deep understanding of the gastrointestinal barriers that limit drug absorption.Experience collaborating or working with the execution of studies utilizing animal models is a plus.Strong record of deliberate mentorship or management of junior level staff.Proven ability to lead the scientific direction of a project.Strong written and oral communication skills for technical and non-technical audiences.Conscientious team member with experience taking and giving constructive feedback.Syntis Bio is pleased to offer:Medical, Dental, and Vision health plans.Flexible time muter transit plan.Flexible Spending Account plan.401(k) retirement plan.STD, LTD, Life insurance plans.Syntis Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, age, sexual orientation, gender identity, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by applicable laws.Syntis Bio uses E-Verify to confirm the identity and employment eligibility of all new hires. #J-18808-Ljbffr

Created: 2025-09-25