Principal Scientist (Director), Anatomic Pathologist

OverviewTranslational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist (Director) to join our innovative team. This position will play a crucial role in supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company's clinical therapeutic pipeline.ResponsibilitiesEngage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company's therapeutics.Collaborate in the development and analytic validation of digital pathology terface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials.Establish new histopathology-based assays in the laboratory as part of a team.Provide subject matter expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders.Position QualificationsEducation Minimum Requirement:Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology.Required Experience and Skills:Proficient in routine histopathology testing, immunohistochemistry (IHC), cytogenetics (in-situ hybridization) testing procedures, and applicable laboratory testing regulations.Experience ensuring compliance of a clinical laboratory with regulatory standards.Experience with the development and analytic validation of digital pathology algorithms.Excellent oral and written skills with a proven record of scientific contributions to the scientific community.Demonstrated ability to lead and manage projects in a fast-paced environment.Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators.Strong understanding of disease processes and pathways relevant to our company's therapeutics.Preferred Experience and Skills:Experience working in the pharmaceutical industry.Broad knowledge of the drug development process and translational medicine.Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.Experience with multiplex tissue-based spatial profiling assays (i.e., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry).Familiarity with image acquisition platforms (e.g., Leica Aperio, Hamamatsu, Pannoramic).Proficiency in commercial or open-source image analysis software packages (e.g., Visiopharm, HALO, QuPath).Knowledge of using statistical software packages (e.g., Prism, SPSS).Understanding of regulated clinical bioanalysis.Current Employees apply HERE. Current Contingent Workers apply HERE.EEO and Compliance: Our company is committed to inclusion and equal opportunity employment and prohibits discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. We comply with applicable affirmative action requirements where applicable.U.S. Hybrid Work Model: Effective September 5, 2023, employees in office-based positions in the U.S. will follow a Hybrid work model with three on-site days per week and remote on Fridays, unless business needs require on-site work. This model does not apply to field-based, facility-based, manufacturing-based, or remote-designated roles, or where a collective-bargaining agreement specifies otherwise.The salary range for this role is $250,800.00 - $394,800.00. The actual offer will be based on factors including education, qualifications, experience, skills, location, and business needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive benefits package including medical, dental, vision, retirement benefits (e.g., 401(k)), paid holidays, vacation, and sick days. More information about benefits is available at the company compensation and benefits page.You can apply for this role through the company careers site.San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records in compliance with local ordinances.Los Angeles Residents Only: We will consider qualified applicants in a manner consistent with local hiring laws and ordinances. #J-18808-Ljbffr

Created: 2025-09-26