Research Scientist, Antibody Discovery and Research

OverviewMapp Biopharmaceutical, Inc. is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio through CMC, Nonclinical, Regulatory, Project Management, and Clinical activities consistent with Mapp/'s product development objectives.The Research Scientist works in the antibody discovery group which is responsible for isolating novel antibodies that may be used in future drug products. This includes creating and producing the antigens necessary to isolate these antibodies and assessing the antibodies for their potential as therapeutics. The Research Scientist, Antibody Discovery and Research will provide overall support for our projects including design, execution, supervision, analysis and interpretation of results.Basic QualificationsPhD or equivalent in biology, molecular biology, biochemistry, virology, and/or related fieldPost doc experience or other appropriate scientific experienceAuthor on scientific publications in respected peer reviewed journalsDemonstrated excellence in the following competency areas:Protein expression in bacterial, mammalian and insect cell systemsProtein purification, including experience with automated HPLC and FPLC systems, fluency in GE Unicorn FPLC softwareFlow cytometry and single B-cell sorting techniquesExperience in leading scientific personnel to execute against program deliverablesExperience with ForteBio Octet technology and isothermal titration calorimetryHands-on experience operating IncuCyte and similar high-content live-cell imaging systemsExperience effectively troubleshooting experimental strategies in the laboratoryPreferred QualificationsExperience with primer design and RT-PCR particularly for monoclonal antibody isolation and cloning from single B-cellsExperience expressing and purifying viral proteinsExperience with reverse genetics and pseudo typed viral vector systemsCommand of in-silico workflows for antibody and protein engineering and optimizationDevelopment of functional cell based assays/immunoassays to assess mechanism of action and potency of new antibody candidates (e.g. reporter assay, internalization assay, neutralization assay, shedding assay ADCC-assay, ADCP-assay, multi-color flow etc.)Generation of stable cell lines using lentivirus transduction and validation of those cell lines via flowcytometry and western blotResponsibilitiesOptimizes and designs expression constructs for protein stability, solubility and expression levelsDesigns and optimizes strategies to generate and purify proteins of interest for subsequent in vitro and in vivo applicationsDesigns and develops novel in vitro assays to assess antibodies for binding and activitySupervises research scientists at various levels as neededReviews and synthesize new research findings regularlyMaintains detailed records of all experiments performedPresents and communicates effectively experimental results to the groupBenefits and CompensationMapp offers a competitive compensation and benefits package. The anticipated pay scale for this position is $80,000 to $130,000 per year plus any applicable bonuses. Final salary offered will depend on factors including education and experience. Benefits include medical, dental, and vision insurance, basic life insurance, short and long term disability, and a 401K plan with company contributions. Full-time employees accrue vacation days, sick time, and holidays as described.This position is on-site at Mapp/'s San Diego facility. Travel is required (Domestic ~2x/year; International ~1x/year).Application and VerificationTo apply, submit your information through the Mapp Biopharmaceutical, Inc. Job Openings website page. This job will remain open for twenty (20) days after posting on Mapp/'s Job Openings website page. No solicitors, agents or placement agencies please. Mapp utilizes E-Verify. Mapp is an equal opportunity employer and employment decisions are not based on protected status. Mapp is an Equal Opportunity Employer/Veterans/Disabled. For more information or to apply now, visit the website: #J-18808-Ljbffr

Created: 2025-09-27