Principal Scientist

OneDigital NorCal HR Consulting provided pay rangeThis range is provided by OneDigital NorCal HR Consulting. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.Base pay range$185,000.00/yr - $215,000.00/yr**Posting for our client, Isotovia Biosciences **We are looking for an outstanding Principal Scientist to join our Discovery team at Isotovia Biosciences, a new company in San Carlos. This individual will be a part of an integrated highly motivated team developing Attobody-based therapeutic molecules. As a vital member, the successful candidate will play a key role in building the foundation of the company’s Discovery organization. This is an on-site position.Key Responsibilities:Responsible for Attobody discovery campaign using yeast and phage display technology, including design, execution and troubleshooting.Perform hands-on Attobody discovery workflow, from library construction, library panning, output screening, single clone attobody characterization and data analysis.Antibody characterization includes affinity and specificity determination, epitope binning and cell binding.Document and maintain ELN (Benchling) with accuracy in a timely mannerOversee outside vendors in matters related to protein production and characterizationConduct in-depth data analysis, communicate data efficiently in project meetings in line with project timeline and goals.Evaluate and assess new technologies and processes that could improve and streamline the discovery workflow.Analyze and interpret data, identify problems, and develop troubleshooting strategies.Proactively review scientific literature and provide strategic input and generate ideas for projectAssesses the needs of a technology platform or Isotovia program and coordinates activities over multiple functions to fulfill company objectives and program goals.Performs other duties as assignedBasic Qualifications:Master’s degree in biology or related field with a minimum of 10 plus years' experience in antibody discoveryOR a PhD in Biology or related field with a minimum of 8 years' experience in antibody discoveryDemonstrated ability to use and design in vitro antibody discovery display technologies (e.g., phage, yeast display) for discovery and/or engineeringSanger sequence analysis experienceExcellent organizational skills and the ability to manage multiple projects simultaneouslyDemonstrated productivity and scientific independence with strong problem-solving skills.Desire to work in a dynamic startup environment is essential.Preferred Qualifications:Strong communication skills to work within a multidisciplinary team environment.Direct experience with Carterra LSA, Biacore SPR, Octet BLI and flow cytometry (iQUE)Experience with robotic liquid handling systems is a plus.Knowledgeable in recombinant protein production and characterizationProficiency in GraphPad Prism, Geneious and BenchlingDemonstrated track record in managing multiple projects and prioritizing tasks to meetschedules and timelines.Excellent written and oral communication skills and the ability to present effectively to teams.Proven contribution to therapeutic antibody development and selection is desirable.Salary range:$185,000-$215,000. The final salary offered is dependent on factors that may include but are not limited to the type and length of experience within the industry, education, etc.Seniority levelSeniority levelMid-Senior levelEmployment typeEmployment typeFull-timeJob functionJob functionScienceReferrals increase your chances of interviewing at OneDigital NorCal HR Consulting by 2xGet notified about new Scientist jobs in San Carlos, CA.Foster City, CA $135,000.00-$185,000.00 1 week agoHayward, CA $125,000.00-$150,000.00 3 weeks agoFremont, CA $110,000.00-$115,000.00 4 weeks agoScientist / Sr. Scientist, Medical HibernationSan Francisco, CA $120,000.00-$180,000.00 2 days agoSan Francisco Bay Area $100,000.00-$150,000.00 2 weeks agoSan Francisco Bay Area $116,000.00-$145,000.00 2 weeks agoSouth San Francisco, CA $57,574.40-$110,635.20 6 days agoScientist I/II/Senior Scientist, Medicinal ChemistryMenlo Park, CA $120,000.00-$180,000.00 14 hours agoAssoc Scientist R&D, RNA Assay DevelopmentHayward, CA $125,000.00-$145,000.00 2 weeks agoScientist I/II, Biologics Cell Line DevelopmentSan Francisco Bay Area $75,000.00-$115,000.00 1 month agoSan Mateo County, CA $60.00-$70.00 2 days agoPrincipal Clinical Research Scientist # 4365South San Francisco, CA $100,000.00-$200,000.00 6 days agoAlameda, CA $86,700.00-$173,300.00 1 week agoScientist — Quality Control Biologics (Clinical Analytical Operations)San Francisco Bay Area $136,340.00-$176,440.00 3 weeks agoDevelopment Associate II to Associate ScientistAI Research, Health, Clinical SpecialistMountain View, CA $146,000.00-$214,000.00 9 hours agoFremont, CA $15,000.00-$250,000.00 1 week agoWe’re unlocking community knowledge in a new way. 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Created: 2025-10-06