Senior Principal Scientist, Cellular & Molecular ...

OverviewAt Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are positioned to innovate across the full spectrum of healthcare solutions today to deliver breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at FunctionDiscovery & Pre-Clinical/Clinical DevelopmentJob Sub FunctionNonclinical SafetyJob CategoryScientific/TechnologyAll Job Posting LocationsSan Diego, California, United States of America; Spring House, Pennsylvania, United States of AmericaAbout Innovative MedicineOur expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.Learn more at Principal Scientist, Cellular & Molecular Toxicology/Translational Safety (location: San Diego, CA or Spring House, PA)PurposeThe Senior Principal Scientist will serve as an integral member of the Cellular & Molecular Toxicology/Translational Safety team in Translational PK/PD & Investigative Toxicology (TPPIT) and Preclinical Sciences & Translational Safety (PSTS) through evaluation and application of model systems for investigations arising from target knowledge and toxicity issues during drug development. This scientist will lead predictive investigative toxicity studies through the design and supervision of scientific and technical activities. The Sr Principal Scientist will communicate plans and updates to PSTS issues teams, project teams, and global leadership in partnership with the Global Lead of Cellular & Molecular Toxicology.You Will Be Responsible ForLead efforts to build and refine robust high-throughput in vitro organ-specific cellular screening workflowsServe as the liaison between High throughput screening, Data Sciences, In Silico Modeling and Preclinical Safety TeamsCollaborate to evaluate external technologies, platforms & CROs for novel in vitro toxicology applicationsOversee conversion of mechanistic cellular, molecular & biochemical toxicology assays into high throughput predictive screening assaysWork with Global Translational Safety Team to establish strategic goals and objectivesCommunicate screening plans and updates to leadership and multidisciplinary teamsMaintain toxicology expertise through collaborations and ongoing educationIdentify topics for internal/external publications and contribute to scientific reportsQualifications / RequirementsEducation: A minimum of a Ph.D. and postdoctoral work in Toxicology, Pharmacology, Biology or related field is required.Skills/ExperienceA minimum of 2-5 years postdoctoral training and 6+ years of relevant work experienceDesigning and conducting mechanistic in vitro studies with high-throughput cell-based modelsExperience with high-throughput organotypic models including immune cellsKnowledge of drug discovery and modalities beyond small molecules (preferred)Advanced knowledge of cellular and molecular toxicology; project leadership experienceCollaborative problem-solving skillsExperience with AI/ML and in silico toxicology modeling (preferred)Experience leading matrixed, multi-disciplinary teamsBoard Certification in Toxicology (preferred)Strong motivation, curiosity, organization, teamwork, and communication skillsThe expected pay range for this position is $137,000 to $235,750. The Company offers competitive compensation and bonuses at the company's discretion. Benefits include medical, dental, vision, life, disability, and retirement plans. Time-off benefits include Vacation, Sick time, Holidays, and Work/Family Time. See for details. #J-18808-Ljbffr

Created: 2025-10-08