Principal Scientist

Get AI-powered advice on this job and more exclusive features.This range is provided by Hamlyn Williams. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.Base pay range$155,000.00/yr - $175,000.00/yrDirect message the job poster from Hamlyn WilliamsAn emerging biotech company located in Los Angeles is seeking a Principal Scientist to lead and expand in vivo pharmacology efforts. This individual will design, execute, and analyze preclinical in vivo studies to support early development programs, guiding therapeutic candidates toward clinical evaluation. You will work alongside an experienced, multidisciplinary team in a fast-paced and collaborative environment.Key ResponsibilitiesDesign and oversee in vivo pharmacology studies assessing efficacy, safety, and mechanism of action of novel drug candidates.Manage all aspects of animal studies, including protocol development, execution, data collection, and interpretation.Develop and refine disease models relevant to CNS disorders.Provide scientific leadership and mentorship to research associates and junior scientists.Collaborate cross-functionally with discovery biology, chemistry, and translational teams to inform candidate selection and optimization.Present experimental findings and strategic recommendations to internal project teams and leadership.Contribute to regulatory documentation, including study reports and IND-enabling submissions.Stay current with scientific literature and apply new methodologies to advance research goals.QualificationsPh.D. in Neuroscience, Pharmacology, Biology, or a related life science field, with 5+ years of relevant industry or academic experience; exceptional Master's degree candidates with extensive leadership experience will be considered.Deep understanding of CNS biology and neurodegenerative or neuroinflammatory disease mechanisms.Proven expertise in rodent in vivo models, including dosing (IV, IP, SC, ICV), behavioral assessments, and tissue/biofluid collection.Skilled in processing biological samples for downstream analyses such as histology, ELISA, RT-qPCR, and imaging.Experience with biologics (antibodies, oligonucleotides, peptides) and their in vivo delivery is highly preferred.Strong data analysis skills and proficiency with relevant software.Demonstrated ability to lead projects, manage timelines, and work independently in a fast-paced environment.Excellent communication, presentation, and cross-functional collaboration skills.Preferred QualificationsHands-on experience with CNS delivery technologies.Experience preparing documentation for regulatory submissions (e.g., IND).Familiarity with GLP/GCP standards for preclinical studies.Seniority levelSeniority levelMid-Senior levelEmployment typeEmployment typeFull-timeJob functionJob functionScience and ResearchIndustriesBiotechnology Research and Pharmaceutical ManufacturingReferrals increase your chances of interviewing at Hamlyn Williams by 2xSign in to set job alerts for “Research And Development Specialist” roles.Los Angeles, CA $80,000.00-$95,000.00 1 month agoResearch & Development Manager (Scientist)Director, Development Research, University Schools & UnitsQuality Assurance Specialist - After School ProgramReforming Process Engineer-Relocate to Saudi ArabiaGardena, CA $130,000.00-$170,000.00 2 months agocGMP Process Development (PD) SpecialistCity of Industry, CA $100,000.00-$120,000.00 2 weeks ago2025-26 Education Specialist (Elementary School)R&D Instrumentation and Lab Equipment EngineerIrwindale, CA $80,000.00-$100,000.00 1 month agoBeverly Hills, CA $55.00-$62.00 2 weeks agoIrwindale, CA $80,000.00-$100,000.00 1 month agoCity of Industry, CA $70,000.00-$85,000.00 4 hours agoQuality Control Subject Matter Expert (SME) – QC InstrumentationLos Angeles Metropolitan Area 2 weeks agoCommunity Services Specialist (Resource Development & Quality Assurance)Quality Control Specialist - MicrobiologyProtocol Development Specialist - Clinical OncologyWe’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. #J-18808-Ljbffr

Created: 2025-10-08