Sr. Director, ADC Drug-Linker Synthetic Process ...

Senior Director, Payload Linker Development At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Position Overview The current opportunity is within the Bioproduct Research and Development (BR&D) organization, which is a multidisciplinary organization focused on the development and commercialization of biologic therapeutics such as monoclonal antibodies and bioconjugates. Due to a strategic commitment to the growth of novel modalities such as Antibody-Drug Conjugates (ADCs) and an exciting pipeline of investigational medicines within the Lilly portfolio, we are seeking outstanding candidates to work at this exciting small molecule biologics interface, focusing on small-molecule drug-linker synthetic chemistry. Position Responsibilities To meet the needs of Lilly's expanding and diverse portfolio of ADCs, we are seeking a highly experienced and strategic Senior Director to lead our payload linker development efforts within the Antibody-Drug Conjugate (ADC) team. This role will focus on the design, optimization, and scaling of payload linker chemistry critical to the manufacturing of next-generation ADC therapeutics. The successful candidate will also exhibit a strong commitment in employee development and thrive in a collaborative and fast-paced work environment. Lead and oversee CMC process development activities for novel payloads and drug-linkers within ADC programs, ensuring alignment with overall program goals. Collaborate closely with Discovery teams to ensure manufacturability and facilitate smooth transition from early research to CMC development. Develop scalable, robust, and reproducible processes for payload linker synthesis, enabling seamless technology transfer from development labs to GMP manufacturing. Build and strengthen internal capabilities by developing team expertise, infrastructure, and technologies related to payload linker process development. Stay current of emerging technologies and scientific advancements in ADC linker and payload chemistry to maintain competitive edge. Champion a strong safety culture in all laboratory activities, ensuring proper handling, containment, and risk assessment practices for highly potent compounds. Provide technical guidance and career development support to team members, including goal setting, performance evaluations, and skills enhancement. Manage external collaborations with vendors and CDMOs specializing in linker and payload synthesis and process development. Ensure compliance with regulatory guidelines and support filing activities for INDs, BLAs, and other regulatory submissions. Basic Requirements Ph. D. in synthetic organic chemistry or relevant scientific discipline with > 8 years of experience; B.S. or M.S. with 15+ years of demonstrated equivalent experience in a related field of expertise. Proven leadership experience managing small molecule CMC development programs and leading scientific teams through all stages of development from discovery handoff to GMP manufacturing and regulatory submission. Extensive expertise and scientific knowledge in linker design, payload chemistry, and related bioconjugation strategies. Proven ability to drive innovation in ADC or small molecule process development, with a focus on implementing novel technologies, improving efficiency, and solving complex scientific challenges. Experience in preparing and contributing to regulatory filings, including IND, IMPD, and BLA submissions, with responsibility for drafting and reviewing CMC-related documentation. Additional Skills/Preferences Experience working in high-potency laboratory environments, including the development of containment strategies and implementation of occupational safety practices, is highly desirable. Experience working with ADC projects, especially regarding the unique CMC and regulatory considerations, is a plus. Strong leadership skills with a track record of building, mentoring, and retaining high-performing technical teams. Excellent cross-functional collaboration and communication skills; able to influence without authority and align internal and external stakeholders. Physical Demands/Travel The physical demands of this job are consistent with a lab and office environment. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $159,000 - $233,200. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees.

Created: 2026-03-04