Principal Investigator

You are applying for a position through Medix, a staffing agency. The actual posting represents a position at one of our clients. Job Summary We are seeking experienced Principal Investigators to provide medical oversight and leadership for clinical trial conduct at our client's research sites. This critical role ensures the highest standards of study integrity, patient safety, and regulatory compliance following a history of successful FDA audits. Key Responsibilities Take full accountability for the clinical conduct and performance of assigned Phase II and Phase III pharmaceutical trials. Maintain a consistent physical presence at the designated research site to provide direct investigator oversight. Conduct final reviews of all Inclusion/Exclusion (I/E) criteria to ensure study volunteers are qualified for participation. Ensure all site activities uphold high standards required for FDA audits and sponsor expectations. Perform real-time documentation of all participant visits and medical assessments using electronic source systems. Adhere to strict electronic signature protocols to ensure all reviews and sign-offs are captured with accurate timestamps. Supervise accurate recording of demographic information and medical histories while maintaining strict volunteer confidentiality. Provide medical guidance and oversight to the site team to ensure study conduct remains within protocol confines. Qualifications A minimum of two years of experience as an investigator in Phase II and Phase III pharmaceutical trials. General Medicine background (Internal or Family Medicine), comfortable managing therapeutic areas such as vaccines, weight loss (GLP-1), and cardiovascular-metabolic trials. MD or DO degree; open to foreign medical degrees provided the candidate holds a valid license to practice in the U.S. Experience with real-time eSource and electronic documentation systems is essential. Candidates should ideally have prior PI experience on at least one study; experienced Sub-Investigators with a strong track record may be considered. Experience Minimum two years of experience in Phase II and Phase III pharmaceutical trials. Specific experience managing clinical trials and investigator supervision. Skills Proficiency in clinical research related to Phase II/III pharmaceutical trials. Strong communication and leadership skills for team alignment and oversight. Benefits Paid Sick Leave (Medix provides paid sick leave according to state and local sick leave ordinances). Health Benefits / Dental / Vision (Medix offers 6 different health plans: 3 Major Medical Plans, 2 Fixed Indemnity Plans (Standard and Preferred), and 1 Minimum Essential Coverage (MEC) Plan. Eligibility for health benefits is based on verifying that an average of 30 hours per week during the first 4 weeks of the work assignment has been met. If you meet eligibility requirements and take action to enroll, you will be covered no earlier than 60 days into your assignment, depending on plan selection(s)). 401k (Eligible on the first 401k open enrollment date following 6 consecutive months on assignment. 401k Open Enrollment dates are 1/1, 4/1, 7/1, and 10/1). Short Term Disability Insurance. Term Life Insurance Plan. We will consider for employment all qualified Applicants, including those with criminal histories, in a manner consistent with the requirements of applicable federal, state, and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance (FCIHO), Los Angeles Fair Chance Ordinance for Employers (ULAC), The San Francisco Fair Chance Ordinance (FCO), and the California Fair Chance Act (CFCA). Medix Overview: With over 20 years of experience connecting organizations with highly qualified professionals, Medix is a leading provider of workforce solutions for clients and candidates across the healthcare, scientific, technology, and government industries. Through our core purpose of positively impacting lives, we're dedicated to creating opportunities for job seekers at some of the nation's top companies. As an award-winning career partner, Medix is committed to helping talent find fulfilling and meaningful work because our mission is to help you achieve yours. This position is subject to a background check based on its job duties, which may include patient care, working with vulnerable populations, access to financial and confidential information, driving, working with heavy machinery, or working in a warehouse or laboratory environment. Due to these job duties, this position has a significant impact on the business operations and reputation, as well as the safety and well-being of individuals who may be cared for as part of the job position or who may interact with staff or clients.

Created: 2026-03-04