Senior/Executive Director, Clinical Pharmacology Lead

Janux Therapeutics is seeking a hands-on, execution-driven Head of Clinical Pharmacology to support the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific contributor who thrives on working directly with data, ensuring high-quality PK analysis, and enabling data-informed decisions for dose selection and regulatory filings. This position is focused on executional excellence and strategy. The key will be producing internal strategic alignment and scientific rigor in deliverables. ESSENTIAL FUNCTIONS AND RESPONSIBILITIES Serve as both the Head of Clinical Pharmacology and Clinical Pharmacology SME/Lead across multiple programs, on both the oncology and immunology side, setting and owning the execution of clinical pharmacology plans from IND through early clinical development (POC). Design and oversee PK, PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments. Propose and lead the development and execution of clinical pharmacology components of studies, including food effect, drug-drug interaction, organ impairment, and QT assessments. Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and support regulatory interactions. Collaborate with Translational Medicine and Biomarker teams to integrate mechanistic and biomarker data into PK/PD interpretation. Work closely with Biometrics and external modeling partners to support population PK and exposure-response modeling. Contribute to program-level planning and prioritization based on pharmacological insights and development risk. REQUIRED EDUCATION, EXPERIENCE, SKILLS, AND ABILITIES M.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field. 12+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry. Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies. Strong expertise in PK analysis and exposure-response interpretation; experience in oncology or immnology preferred. Experience managing external Clinical Pharmacology resources. Proven track record of contributing to regulatory submissions and engaging with health authorities. Excellent communication, collaboration, and organizational skills. Ability to work independently and in a fast-paced, matrixed environment. Ability to travel up to 15%. $260,000 - $320,000 a year In addition to a competitive base salary ranging from $260,000 to $320,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available. Please note that the hourly rate range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, and internal equity. Job Type: Full-time Benefits: • Annual bonus program • Incentive stock option plan • 401k plan with flat non-elective employer contribution • Comprehensive medical insurance with 90-100% employer-paid premiums • Dental and vision insurance • HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity) • Unlimited PTO • Generous holiday schedule; includes summer and winter company shutdown • Relocation assistance Schedule: • Monday to Friday Work authorization: • United States (Required) Additional Compensation: • Annual targeted bonus % Work Location: • On site (San Diego, CA) EQUAL OPPORTUNITY EMPLOYER: Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity. Notice to Recruiters and Third-Party Agencies The Talent Acquisition team manages the recruitment and employment process for Janux. To protect theinterests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Created: 2026-03-04