Senior Manager, Clinical Bioanalytical Outsourcing

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Clinical Bioanalytical Lead is responsible for the strategic oversight and operational execution of bioanalytical activities supporting clinical development programs. This role serves as the primary point of contact for Contract Research Organizations (CROs) performing bioanalytical method development, validation, and sample analysis, ensuring high-quality, compliant, and timely delivery of bioanalytical data to support clinical trials and regulatory submissions. Act as the primary scientific and operational liaison for bioanalytical CROs supporting clinical studies. Provide oversight of CRO bioanalytical activities including method development, validation, sample analysis, and data reporting. Review and approve bioanalytical sample analysis plans, validation reports, bioanalytical reports. Draft and review the pharmacokinetics components of a clinical protocol, lab manual and other study associated documents. Ensure CRO performance meets agreed timelines, quality standards, and contractual obligations. Lead issue resolution, deviation investigations, and CAPA discussions related to bioanalytical work. Partner closely with Clinical Pharmacology, Clinical Operations, Clinical Data Science, and Quality teams. Contribute to integrated development team discussions and provide bioanalytical expertise across programs. Ensure bioanalytical activities are conducted in compliance with GLP/GCP, internal SOPs, and regulatory guidance. Maintain inspection-ready documentation and traceability for all bioanalytical activities. Facilitate clinical PK header reconciliation. Required Skills, Experience and Education: MS in Analytical Chemistry, Pharmacokinetics, drug metabolism or a related scientific discipline with 7 years of relevant industry experience, or BS with over 10 years of relevant industry experience. In-depth knowledge and hands-on experience with LC/MS/MS and quantitative analysis of small molecules in complex biological matrices. Knowledge and hands-on experience with large molecule quantitation in complex biological matrices. Good understanding of regulatory guidelines for regulated bioanalysis. Experience in regulatory BA submissions, interactions and addressing IRs from regulatory agencies. Excellent interpersonal, oral, and written communication skills. Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, small company environment. Preferred Skills: Hands on experience in GLP. Experience in supervising BA CRO. Experience in supporting NCA in Phase 1, Phase 2 clinical trials. #LI-Hybrid #LI-CT1 The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact . Base Pay Salary Range $164,000-$205,000 USD We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you've been contacted by someone impersonating a Revolution Medicines recruiter, please report it to so we can share these impersonations with our IT team for tracking and awareness.

Created: 2026-03-04