Senior Director, Toxicology

Job Title: Senior Director, ToxicologyLocation: Thousand Oaks, CA or San Francisco, CAPosition Type: Full TimeCompany Description:Latigo Biotherapeutics, Inc. is a private, early-stage biotechnology company focused on discovering and developing the next generation of non-opioid medicines for pain and pain-related syndromes. Our mission is the development of novel therapies that transform the lives of patients. The company is headquartered in Thousand Oaks, CA and has a highly successful management team and an experiencedBoard of Directors. At Latigo, we value science, patient-focus, and innovation. Position Description: The Senior Director of Toxicology will provide strategic and scientific leadership for all aspects of nonclinical safety and toxicology across Latigo's discovery and development pipeline. This role is accountable for defining and executing phase-appropriate nonclinical safety strategies to support candidate selection, IND-enabling activities, first-in-human (FIH) studies, and overall clinical development for small molecule programs.As a recognized subject matter expert, the Senior Director will serve as a core member of cross-functional project teams and a key contributor to regulatory strategy. This individual will oversee internal and external toxicology resources, mentor and develop nonclinical scientists, and ensure high scientific rigor, regulatory compliance, and efficient execution of nonclinical safety programs.Key ResponsibilitiesStrategic & Scientific LeadershipLead the overall nonclinical safety and toxicology strategy from early discovery through IND submission, clinical development, and NDA submission.Serve as the toxicology and nonclinical safety SME on cross-functional project teams, providing clear risk-benefit assessments and strategic recommendations.Define target safety profiles and guide compound progression decisions in partnership with Discovery, DMPK, Clinical Pharmacology, and Clinical Development teams.Study Design & ExecutionDesign, oversee, and interpret IND-enabling toxicology and safety pharmacology studies, ensuring alignment with regulatory expectations and development timelines.Provide scientific oversight of CROs, consultants, and vendors, including study design, protocol review, data quality, and final report approval.Ensure nonclinical safety and toxicology programs are scientifically sound, efficiently executed, and appropriately staged for development phase.Regulatory & CompliancePartner closely with Regulatory Affairs to author, review, and approve nonclinical sections of INDs, IBs, briefing documents, and regulatory responses.Support regulatory interactions (FDA and ex-US), including pre-IND, end-of-Phase 2, pre-NDA, and other regulatory meetings.Ensure compliance with GLP, ICH, and FDA regulatory guidance applicable to nonclinical safety.People & Organizational LeadershipBuild, mentor, and develop a high-performing nonclinical safety team, fostering scientific excellence and collaborative culture.Contribute to the evolution of nonclinical processes, standards, and best practices as the organization scales.Act as a thought partner to senior R&D leadership on portfolio strategy and organizational capability development.Qualifications & ExperiencePhD, DVM, or equivalent in Toxicology, Pharmacology, or a related scientific discipline.15+ years of industry experience in nonclinical safety/toxicology within biotechnology or pharmaceutical settings.Demonstrated leadership of toxicology programs for small molecule therapeutics from IND-enabling studies through marketing applicationsStrong track record of regulatory authorship and agency interactions supporting early development programs.Proven ability to lead cross-functional teams and influence development strategy at the program and portfolio level.Experience in therapeutic areas related to pain or neuroscience is preferred.Core CompetenciesDeep scientific expertise in nonclinical safety and toxicologyStrategic thinking with strong execution focusClear, persuasive scientific communicationCollaborative leadership and people developmentComfort operating in a fast-paced, early-stage biotech environment

Created: 2026-04-02