Computational Biologist

About NewLimitNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.DescriptionNewLimit is seeking a Computational Biologist to join our Predict team. In this role, you will develop, improve, and operate bioinformatics pipelines supporting large-scale single-cell perturbation screens. Success in this position requires a deep attention to methodological detail at every stage of the analysis, as well as careful measurement and evaluation of pipeline performance.You will work closely with experimentalists and computational scientists to maintain core infrastructure, assess emerging analysis tools, and build robust software solutions that improve efficiency, scalability, and reliability.As a member of our team, you will:Collaborate with Write, Read, and Predict teams to support the design, execution, and interpretation of experiments using single-cell and multi-omics dataContribute to the development and implementation of primary and secondary analysis software.Improve and run production pipelines for large-scale single-cell perturbation screens to ensure timely and reliable data deliveryContribute to the development of reproducible, well-documented computational workflows and internal best practicesDevelop microservice web applications and integrations that reduce wet lab manual effort and improve data flow between teamsRequirementsBachelor's, Master's, or PhD in Bioinformatics, Biostatistics, Computational Biology, Computer Science, or a related technical fieldExperience analyzing and interpreting single-cell or multi-omics datasets (e.g., scRNA-seq, multiome, scATAC-seq), with hands-on exposure to perturbation screens preferredFamiliarity with core single-cell bioinformatics workflows, including demultiplexing, alignment, and quality controlStrong software engineering fundamentals and experience working with bioinformatics tools and pipelinesWorking knowledge of statistical and machine learning methods applied to biological data (e.g. regression analysis, supervised learning) sufficient to critically evaluate analytical choices and interpret results conceptuallyNice to havesProficiency with Python-based data science tools (NumPy, SciPy, Pandas)Experience with cloud computing environments (AWS, GCP, or Azure)Strong Python programming skills and comfort working in Unix-based environmentsExperience with containerized workflows (Docker, Singularity)Familiarity with molecular biology workflows and experimental genomicsBenefitsHealth, dental, and vision insurance401(k) with company matchIndustry-leading paid time off (PTO) -- 20 days/year for all employees + holidaysPaid parental leaveMeals and snacks on-siteSalary Range: $130,000 to $170,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

Created: 2026-04-02