Global Therapeutic Research Lead, Neuroscience - ...

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy NoticeandTerms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge. Leveraging a proven track record of leading at least 3 discovery programs to clinic, The Global Therapeutic Research Lead (G-TRL) is a pipeline critical strategic leader responsible for driving Research projects to the clinic. The individual will sit on the Neuroscience Drug Discovery Unit (NS DDU) Leadership Team. ~ Leader for at least one or more of Takeda’s top priority small molecule projects with substantial clinical and commercial potential with a clear accelerated path to the clinic. ~ You will provide mentorship to team members to elevate enterprise thinking and capabilities of our drug discovery talent across the global Research function. ~ As project lead, the G-TRL builds a connected view of the project within the Neuroscience TA strategy and treatment paradigm and can represent all core expertise at depth and align with stakeholders and sponsors across the organization including Research, Clinical Development and Commercial stakeholders and executive level governance committees. ~ G-TRLs are responsible for creating the medicine vision, early asset strategy and managing multiple external partnerships that accelerate delivery of the project. ~ G-TRL will advise on the continuous infusion of new Research projects aligned to strategy to generate a sustainable Research Engine generating a steady flow of high-quality INDs every year.Lead and manage one or more ‘Top 10’ drug discovery molecule projects, overseeing the entire drug discovery process from target identification to preclinical development. (Top 10 projects are well validated targets that are focused on strategically aligned modalities with substantial clinical and commercial potential) Responsible for the articulation and ownership of the project strategy, developed in partnership with internal stakeholders. Contribute to strategy for future portfolio investment, particularly within the Inflammation and Immunology area including advising on which projects should be Top 10 projects. Evaluate and prioritize potential drug candidates based on scientific, medical, and commercial considerations. Represent all core expertise for project. Partner with Clinical and Translational teams to refine asset strategy. Clinical Development). Understand and align with commercial team for asset commercial value within the Neuroscience Therapeutic Area (NS TA). Provide guidance and mentorship to global project team members, stimulating enterprise thinking and fostering their professional growth and development. Mentor future and more junior project leads and elevate drug discovery capability across Research. DMPK, Pharmaceutical Sciences) within and outside Takeda to drive project delivery. Pipeline and enterprise impact through effective partnering with multiple internal and external collaborators. Provide strategic, process, and operational leadership for successful Top 10 Project delivery. Foster a culture of innovation and scientific excellence within the matrixed drug discovery team, promoting collaboration, knowledge sharing, and continuous learning. Become a world leading scientific expert in the projects you lead. Oversee the design and execution of experiments, data analysis, and interpretation to enable decision-making and optimize drug discovery efforts. Stay abreast of the latest advancements in drug discovery, emerging technologies, and industry trends, applying this knowledge to enhance drug discovery strategies. Build and maintain relationships with key stakeholders, including academic institutions, research organizations, and industry partners inclusive of serving on joint external governance committees across the globe. Represent Takeda externally for the Neuroscience Drug Discovery Unit and play a key role in evaluating external opportunities, serving as an effective ambassador for Takeda’s global business development brand.Advanced degree in health or life sciences (e.g., Expected to have at least 10-12 years industry and relevant subject matter expertise within Immunology and Inflammation and at least 10-12 years global management experience, including working effectively with matrix teams. Extensive experience in leading drug discovery teams and managing drug discovery/development projects, preferably in a pharmaceutical or biotechnology setting covering gastroenterology and inflammation. Deep understanding of the drug discovery process, including target identification, hit-to-lead optimization, and preclinical development, anticipating, and removing roadblocks. Proven track record of leading numerous projects, ideally 5+ projects, across discovery from target inception to Candidate Nomination or beyond. Has delivered clinical development assets in small molecules and have insight into oligonucleotide and biologic modalities Strong business acumen and understanding of the pharmaceutical industry, including regulatory requirements and commercial considerations with relevant knowledge and expertise for specific modalities. Exceptional communication and presentation skills, with the ability to effectively communicate complex scientific concepts to diverse audiences. Strong problem-solving and decision-making abilities, with a focus on data-driven decision making. Demonstrated success in building and managing strategic partnerships with academic institutions, research organizations, and industry collaborators. As part of our global R&D strategy, and unique to the Research organization’s strong lab presence in Shonan, Japan, this role may include the opportunity for a temporary or long-term international assignment in Japan, subject to business needs and final candidate selection. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policyThe actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.S. based employees may be eligible for short-term and/ or long-term incentives. S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.

Created: 2026-04-06