Senior Manager-Clinical Bioinformatics Operations

Kforce has a client that is seeking a Senior Manager, Clinical Bioinformatics Operations in Marlborough, MA. The Opportunity: A leading national health technology firm is seeking a high-caliber Senior Manager of Bioinformatics Operations to lead a regional team dedicated to scaling high-throughput clinical diagnostics. In this leadership role, you will bridge the gap between complex genomic engineering and daily lab operations, ensuring our precision medicine pipeline remains stable, compliant, and cutting-edge. The Role: As a regional operational lead, you will oversee the deployment, validation, and maintenance of automated computational pipelines. You will partner with cross-functional stakeholders-including laboratory scientists, IT infrastructure, and R&D engineers-to deliver high-quality diagnostic applications that meet rigorous clinical turnaround times and regulatory standards. Key Responsibilities: * Team Leadership: Mentor a regional team of 5-7 bioinformatics scientists and contractors, fostering a culture of technical excellence and accountability * Operational Oversight: Manage daily production pipelines, ensuring 24/7 service levels and performance targets are met for patient reporting * Production Support: Collaborate with wet-lab operations to troubleshoot processing issues and manage incident response for production environments * Process Engineering: Drive best practices in CI/CD, workflow orchestration, and system health monitoring to ensure "always-on" availability * Compliance & Data Integrity: Maintain robust documentation for regulatory audits and ensure secure, compliant archival of sensitive genomic data * Strategic Alignment: Partner with peer managers to standardize operational frameworks and support the rollout of new diagnostic products * Professional Development: Implement training modules and competency assessments to upskill the technical team* Experience: 7+ years in bioinformatics, computational biology, or software engineering within a production environment * Technical Stack: Proficiency in Python, R, Shell scripting, SQL, and cloud architecture (AWS preferred) * Domain Expertise: Hands-on experience with secondary analysis tools (aligners, variant callers) and clinical interpretation workflows * Leadership: Proven track record of managing technical teams and delivering "clinical-grade" software solutions * Regulatory Knowledge: Familiarity with high-complexity laboratory environments (e.g., CAP/CLIA or similar quality frameworks) * Communication: Ability to translate complex technical challenges into actionable strategy for non-technical stakeholders Preferred Experience: * Advanced degree (MSc or PhD) in a relevant computational field * Experience integrating with LIMS or third-party variant interpretation platforms * Familiarity with Agile methodologies and managing distributed or international teams Why Join Us: We offer a mission-driven environment focused on transforming patient care through data. Our benefits package includes comprehensive health insurance, retirement matching, tuition reimbursement, and clear pathways for executive leadership growth.

Created: 2026-04-15