VP, Early Development - Clinical Science

About the RoleThe Vice President, Early Development - Clinical Sciences provides strategic and scientific leadership for early development clinical programs, overseeing trial direction, design, execution and data interpretation from first-in-human through proof-of-concept and beyond. A primary focus of this role is to create an adaptable early development clinical strategy to support innovative early development trials that require creative, forward-thinking approaches to study design, endpoints and operational strategy. This leader will challenge conventional paradigms, applying rigorous scientific judgment and out-of-the-box thinking to inform key development decisions.This position will partner cross-functionally with Clinical Operations, Regulatory Affairs, Translational Sciences, Medical Affairs, Finance and Legal to drive efficient and scientifically rigorous early development clinical work. This person will also work closely with the Business Development team and will be involved in clinical due diligence.Let's talk about some of the key responsibilities of the role:Maintains an active, hands-on role in clinical strategy and execution, directly contributing to protocol development, study design decisions, data interpretation, and cross-functional problem solving that can rapidly and robustly assess proof-of-concept in early trialsProvides leadership and strategic oversight in the determination of study strategy, objectives, scope and schedule to meet business needs; align the team on common priorities and initiativesEnsures the leadership team is kept informed of study progress and that all critical issues are appropriately escalated within the organizationExhibits and fosters key leadership competencies, including an innovative mindset, strong business acumen, an outcome-driven orientation, and a commitment to growing and expanding the capabilities and capacity of the teamDrives innovation by identifying and integrating cutting-edge technologies and methodologies into early development clinical trial designShapes clinical plans including timelines, budgets and oversight of clinical teamsRepresents the company with investigators, regulators and executive leadershipDrive contributions focused on generating information that supports safe use, patient targeting, and clinical/commercial positioningReviews/interprets clinical data across early/mid-stage studiesServe as a senior leader, participating in the broader leadership team and guiding strategic decisionsActively partners with Clinical Operations, Regulatory Affairs, Translational Sciences, Biostats, Operations, Medical Affairs and Commercial teams to drive company and asset strategyFactors for Success:Advanced degree(s) in relevant field (e.g. PharmD, MD, PhD) with deep experience in early clinical developmentExperience in ophthalmology is preferred; dermatology or infectious diseases a plus.Minimum of 15 years of biotech/pharmaceutical industry based clinical experience with hands-on experience designing and executing early proof-of-concept and Phase 1 clinical trialsAbility to communicate complex scientific concepts across internal and external audiences, and the ability to influence cross-functional teamsEstablished strategic leadership track record with evidence of excellent people management experience, problem solving, collaboration, and cross functional leadershipPrior experience in clinical development at a start-up or small pharmaceutical company preferredDemonstrated ability to develop and execute drug development strategic plans, to develop contingency plans, to provide technical and strategic advice, and to meet milestones and budgets.Must be willing to be "hands on" and delve into detailsLeadership Competencies - This role requires mastery of the Tarsus Leadership Competencies for Leading Teams, including:Empowering Others - Fosters empowerment by aligning authority with accountability, developing leaders' decision-making capability, and creating systems that support performance and growth.Emotional Intelligence - Foster trust and psychological safety, navigating complex interpersonal dynamics with compassion and accountability, and adapting leadership style to support others while maintaining composure under pressure.Grows Capacity - Builds organizational capacity by developing talent systems, coaching cultures, and strategic partnerships that grow leadership strength and prepare the next generation of leaders.Business Acumen - Demonstrates strong business acumen by anticipating market dynamics and using financial and strategic insight to guide investments, manage risk, and align priorities with long-term organizational value.Innovative Mindset and Action - Demonstrates an innovative mindset by championing new ideas, investing in enabling systems and partnerships, and translating innovation into sustainable growth and organizational resilience.A Few Other Details Worth Mentioning:The position will be based in our beautiful Irvine office, complete with onsite gym, pool, snacks, drinks, and occasional catered meals. We provide a hybrid work environment. Remote work is an option.We are passionate about our culture! Our Tarsans live our values of commitment to patients, empowerment to champion innovation, and teamwork to amplify impact!This position reports directly to our SVP, DevelopmentSome travel may be required - up to 40%At Tarsus, we understand the importance of attracting and retaining top talent. The expected base pay range for this position is $300,000 - $420,000 plus bonus, stock equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. Our benefits include health, dental and vision insurance benefits to ensure your well-being. We believe in work-life balance and offer generous paid time off, including vacation, holidays, and personal days. For more details regarding Tarsus benefits, please visit: Pharmaceuticals, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected Veteran Status, or any other characteristic protected by applicable federal, state, or local law.

Created: 2026-04-15