Postdoctoral Fellow-MSH

Job Description _Roles & Responsibilities:_ Position Overview Icahn School of Medicine at Mount Sinai, NYC is seeking to hire a medicinal chemistry postdoctoral fellow for novel small molecule drug discovery projects in interesting therapeutic areas of unmet medical need including diabetes, orphan disease, neuroscience, IBD and oncology. The role will require the structure-based drug design and synthesis of novel medicinal compounds for testing in in vitro and in vivo assays that support the basic biology and drug discovery research efforts. PhD in medicinal chemistry or organic synthesis required. Duties and Responsibilities Docking and structure-based drug design based on known ligands and X-ray crystallography co-crystal data available from collaborator labs. Preparation, purification and characterization of compounds in chemistry laboratory; documentation of all experiments in electronic lab notebooks (ELN) including written, publication quality, experimental procedures. Operation and maintenance of laboratory instruments - HPLC and LC-MS for example. Safe laboratory habits and experimental practices. Opportunities for professional development The position will allow the candidate to develop valuable new skills and experience in early drug discovery and chemical biology in a highly collaborative research environment. These include: Collaborate to validate novel biological targets Chemical biology tool synthesis and development Structure-based drug design; Schrodinger software suite High throughput screening hit validation and analysis Hit and Lead identification Lead optimization medicinal chemistry and pre-clinical candidate selection Analysis of in vitro and in vivo activity of compounds (pharmacodynamics) Chemo and bioinformatics database development and data analysis Optimize physical-chemical properties of drug molecules Study Absorption, Distribution, Metabolism and Excretion (ADME) properties Evaluate drug metabolism and pharmacokinetics (DMPK) in preclinical species External collaboration and public presentation skills _Requirements:_ PhD Qualifications . Responsibilities . About Us Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinaiu2019s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time u2014 discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patientsu2019 medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high

Created: 2025-10-04