Postdoctoral Fellow-MSH-30040-225

Job Description Title: Postdoctoral Scholar Department: Pharmacological Sciences Physical work location: (must be proper street address): 1425 Madison Ave, New York, NY 10029 Name PI or Supervisor: (include phone and email): Min Xue, 212-6598218, Web link to Lab: Web link to Department: Administrative Contact: (phone and email): Yoori Kim, 212-6598651, Qualifications Educational and other Requirements for the position: Ph.D. in Chemistry or related discipline Experience Required: + Cyclic peptide chemistry and solid-phase peptide synthesis. + Cell-penetrating peptide (CPP) design and biochemistry. + Chemical biology techniques relevant to peptide modification and conjugation. + High-throughput screening (HTS) and data-driven hit validation. + Analytical characterization (LC-MS, HPLC, mass spectrometry). + Functional biochemical or cell-based assays. + Strong organizational, documentation, and communication skills. + Ability to work both independently and collaboratively in a fast-paced research environment. Goals/Outcomes of the Research Project: The postdoctoral researcher will drive a program aimed at: + Identifying novel cyclic peptide ligands for specific cell-surface receptors. + Developing delivery-competent peptide scaffolds withoptimized receptor binding and cell penetration. + Generating and characterizing drugu2013peptide conjugates for targeted delivery. + Producing mechanistic insights that support preclinical development. + Delivering high-impact publications, technology disclosures, and potential translational opportunities. Successful completion of this project is expected to yield receptor-targeting cyclic peptides that advance drug delivery for oncology, immunology, and molecular imaging applications. Responsibilities Details of Research Project: The overarching goal of this project is to develop receptor-targeting cyclic peptides for drug delivery. The successful candidate will design, synthesize, and characterize novel peptide scaffolds engineered for improved receptor binding, enhanced stability, and optimized delivery properties. These peptides will be integrated into drug conjugates and delivery vehicles to improve therapeutic index, tissue specificity, and cellular uptake. The research spans molecule design u2192 synthesis u2192 in vitro evaluation u2192 functional screening, with opportunities for collaboration across structural biology, proteomics, and disease-focused groups. Technical Duties: (include any protocols) u00b7 Peptide Synthesis & Purification + Conduct solid-phase and solution-phase synthesis of cyclic and multicyclic peptides. + Optimize cyclization and bioconjugation chemistries. + Purify peptides using HPLC and other chromatographic methods. u00b7 Design & Engineering of Novel Peptide Scaffolds + Develop new backbone architectures, linkers, and receptor-binding motifs. + Apply structureu2013activity insights to improve affinity, permeability, and stability. + Design cell-penetrating and receptor-targeting sequences for delivery applications. u00b7 Analytical & Functional Assays + Characterize peptides using LC-MS, MS/MS, NMR (as applicable), and biophysical assays. + Perform biochemical, cellular, and reporter-based functional assays. + Conduct in vitro uptake, trafficking, and delivery efficiency studies. + Participate in high-throughput screening (HTS) and hit validation pipelines. About Us Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinaiu2019s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time u2014 discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patientsu2019 medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. 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Created: 2025-11-19