Computational Biologist 2

The OHSU Knight Cancer Institute is internationally recognized for pioneering advances in personalized cancer treatment and early detection. From transforming Chronic Myeloid Leukemia with Gleevec to driving precision oncology, the institute is dedicated to ending cancer as we know it. Our culture is guided by three principles: we are bold, we are supportive, and we work as a connected team. The Knight Diagnostic Laboratories (KDL) is a CLIA/CAP-accredited diagnostic laboratory with decades of expertise in molecular oncology, rare genetic disorders, and cytogenetics. Our team of medical directors, scientists, and technical specialists provide cutting-edge diagnostic testing to enable personalized medicine. Additionally, through close partnerships with the Knight BioLibrary and Histopathology Shared Resource Laboratories, our clients can also gain access to biospecimens, histology, and immunohistochemistry services.Every Knight Cancer employee is expected to embody our guiding principles:We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differentlyWe SUPPORT each other—Respect leads to trust, which leads to excellenceWe work as a CONNECTED team—We must leverage our collective brain power to conquer cancer because no one individual can do it alonePosition Summary - We are seeking a Computational Biologist / Clinical Bioinformatician to join our multidisciplinary team. This role provides bioinformatics expertise in support of clinical test development and will work closely with medical directors, bioinformaticians, and wet-lab scientists to develop, validate, and maintain clinical workflows in accordance with CAP and regulatory standards. The successful candidate will bring strong experience in next-generation sequencing (NGS) data processing and analysis (tissue, blood, and cell-free specimens; OR: DNA, RNA, epigenomics), and bioinformatics tool development and biostatistics, with a commitment to teamwork, reproducibility, and clinical best practices.Key Responsibilities:Support clinical test development through computational analysis of data and development of computational tools.Develop, validate, and maintain bioinformatics pipelines aligned with CAP/CLIA requirements.Implement and benchmark tools, algorithms, and workflows for variant calling, expression analysis, and proteomic profiling.Collaborate with medical directors, clinical bioinformatics teams, and wet bench scientists in a cross-disciplinary environment.Contribute to SOP-driven analysis workflows, ensuring reproducibility and regulatory compliance.Manage and maintain code, data, and version control repositories (e.g., GitHub).Provide bioinformatics support for clinical reporting and test development.Stay current with emerging literature, methods, and tools in computational biology and clinical bioinformatics.Participates in the supervision of trainees involved in computational projectsMaster's Degree in Computational Biology or related field AND 3 years of relevant experience OR Bachelor's Degree in Computational Biology or related field AND 6 years of relevant experience1 year of clinical experience in NGS data analysis including variant calling, copy number analysis and structural variant interpretation1 year of clinical Bioinformatics Tools & Pipelines: Alignment (BWA, STAR, HISAT2); Variant callers (Mutect2, VarScan, Strelka, FreeBayes); Annotation tools (ANNOVAR, VEP, Oncotator); Workflow management (Nextflow, Snakemake, WDL/Cromwell)Demonstrated ability to develop genomic analysis workflows.Demonstrated skills in a high-level programming language, preferably Python or R, Pearl, preferably in Linux or Unix, optionally with Java or C/C++Experience with artificial intelligence methods.Experience with SOP-driven workflows for reproducibility and accreditation complianceExperience with statistics and its applications to data analysis and interpretationExperience with structured data storage and with multi-component data processing systemsExperience with architecture or tools for managing “omics” or imaging dataAbility to prioritize multiple tasks at one timeExcellent communication, analytical and organizational skills: both written and verbalAbility to work independently and as part of a team while being collaborative in resolving problemsIntermediate skills with Microsoft Office (Excel, Outlook, Access, Word, and PowerPoint) on Window OS. Ability to accurately type 60wpmWorking knowledge of OracleMust have demonstrated excellent customer service skills both on the phone and in personMust possess energy and drive to coordinate multiple projects simultaneouslyAbility to use tact and diplomacy to maintain effective working relationshipsPhD in Computational Biology or related fieldExperience as a data analyst, data scientist, software developer or biostatistician, including at least 6 months in a collaborative teamwork environment.Clinical report generationExperience with AWS data workflowsFamiliarity with CLIA/CAP regulations for molecular diagnosticsHigh-performance computing experienceExperience developing, training, and implementing AI-based tools.Apply online. Please be sure to upload a Cover Letter and Resume/CV. We offer a variety of benefits on top of joining a thriving organization:Medical, dental and vision coverage at no or low cost to employeesCovered 100% for full-time employees and 88% for dependentsSeveral retirement plans to choose from with contributions from OHSU25 days a year of paid time off8 days of sick time off Commuter subsidiesTuition reimbursementAccess to group life insurance, disability insurance and other supplemental benefitsAnnual Merit IncreaseGrowth/Development OpportunitiesEmployee discounts to local and major businesses#linkedin #indeed #knightcancerjobs#knightresearchandlabjobs#knightcompbiojobs #knightinternalOregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or .

Created: 2025-12-25