Sr. Principal - Engineer - Automation (Small Molecule)

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Weu2019re looking for people who are determined to make life better for people around the world. At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism Lilly is currently constructing an advanced manufacturing facility for production of API molecules located in Houston, TX. This facility is intended to provide APIs for current and future products, including new modalities. This is a unique opportunity to be a part of the site technical team for the startup of a greenfield manufacturing site, and the successful candidate will help to build the organization, the facility and the culture to enable a successful startup into GMP manufacturing operations. Responsibilities: The Sr. Principal - Engineer (Automation - Small Molecule) is a senior automation position that will lead the design and delivery of the DeltaV platform and associated software integration teams as part of Lillyu2019s manufacturing expansion. This role is intended to lead one or more project workstreams for the automation DCS function including design, scheduling, staffing, and qualification in the Drug Substance (Active Pharmaceutical Ingredient) network. During the design and delivery (startup expected 2029 to 2030) of the project this role will be integrated into the corporate delivery team leading one or more workstreams on the design, delivery, and startup of drug substance manufacturing focusing on Small Molecule. This role will collaborate with A&E firms, system integrators, corporate and site engineering peers, and 2019s corporate IT team) develop and manage the DeltaV DCS system and software design, testing, startup, and qualification. The Automation Engineer is a site-based position but will be closely integrated with Lillyu2019s Corporate Automation Team GPACE. GPACE (Global Process Automation & Control Engineering) provides automation, measurement, and process control solutions to Lilly manufacturing as well as a technical resource for training, standards, and capital project delivery. Post project delivery, this role will support GMP manufacturing operations in small molecule or oligonucleotides. This will require significant collaboration, creativity and resilience as the site grows to a full scale GMP manufacturing through start up. Key Deliverables: + Champion a strong safety culture, mentor and coach others, and utilize engineering and automation fundamental principles in design and problem solving. + Collaborate with Lilly engineering, A&E firms, and system integrators to develop requirements and specifications that will be the foundation for software development and system architecture. + Manage one or more system integrators for fully deliver and test DeltaV software. + Collaborate with deliver a fully integrated Automation/MES solution that is scaled for the needs of business. + Participate in basic and detailed design that also includes staffing, statements of work, supplier management, and delivery strategies for automation systems. + Participate in developing computer system validation strategies. + Develop and build capabilities within the Houston site automation team. + Develop site procedures for automation platforms and associated administration activites. + Provide engineering support for Process Safety Management (PSM) and Process Hazard Reviews (PHRs). + Provide technical oversight during development of equipment and process system User Requirements and related Design Review/Qualification documentation to ensure equipment and systems are appropriate for intended purpose. Basic Qualifications: + Bacheloru2019s degree in engineering or related applicable discipline required. + 5+ years of experience Process Automation with experience on the Emerson DeltaV Platform preferred. Other platform experience will be considered. + 5+ years of experience in API/Drug Substance manufacturing preferred. Related manufacturing experience will be considered.

Created: 2026-03-07