Principal Scientist

Overview WuXi Biology at San Diego, a division of WuXi AppTec Company, is seeking a highly motivated and established Principal Scientist with deep and broad expertise in Immunology drug discovery and research. The Principal Scientist will lead a group of junior scientists at the San Diego site to provide scientific services and solutions to our customersu2019 drug discovery research needs. Responsibilities u2022 Manages and leads a group of junior scientists in In Vitro Immunology team to execute a variety of scientific projects to ensure successful execution of projects and best quality services. u2022 Leads from the bench, builds and grows a high-performance team, provides effective mentorship and coordinates collaborations with colleagues from the same team and other cross-functional teams. u2022 Establishes and ensures delivery of financial and productivity goals. u2022 Provides innovative scientific proposals, identifies and implements emerging key technologies to expand service capabilities and fulfill customer needs in cutting-edge drug discoveries. u2022 Responsible for drafting scientific proposals to provide solutions tailored to Clientu2019s needs. u2022 Responsible for coordinating efforts and facilitating communication to ensure alignment between different units and our customers. u2022 Provides support and participates in business development activities to promote services and engage new customers. u2022 Ensures operation compliance of EHS rules and government regulations for all members of the in vitro Biology team u2022 Perform job specific tasks in compliance with applicable Regulations, International Standards, and WuXi AppTec Policies and Standard Operating Procedures. u2022 Other duties as assigned. u2022 May be required to assist in other departments. Qualifications Experience / Education u2022 Ph.D in immunology, molecular biology or related field with a minimum of 6 years of Biotech/Pharmaceutical/CRO working experience. u2022 Experienced with in vitro cell-based assays and scientific proposal/report writing. Knowledge / Skills / Abilities: u2022 Demonstrated broad expertise in immunology. u2022 In-depth knowledge and hand-on experience in vitro disease-relevant models, including using human whole blood, PBMC, and isolated immune cell subsets, for autoimmune disease research and drug discovery. u2022 Have a mindset from in vitro, to in vivo and clinical translation to continuously improve the data translatability during in vitro assay development. u2022 Knowledge of in vitro pharmacology assay development, validation and compound screening for different drug modalities, such as small molecule inhibitor/modulator, mAb, depleting mAb, bispecific, multi-specific, antibody oligonucleotide conjugate, antibody drug conjugate, antibody-conjugated nanoparticles with various payloads (small molecules, peptides, hormones, and various RNA moieties). u2022 Experienced in managing team(s) to include junior scientists and research associates. Demonstrated ability to guide groups through team change and growth. u2022 Strong communication skills with collaborators and clients, and the ability to present information clearly and professionally to varying levels of individuals. u2022 Ability to work effectively in team settings, build collaborative relationships with customers, managements, and peers from diverse backgrounds. u2022 Thorough understanding of Good Laboratory Practices and Good Manufacturing Practices. Physical Requirements: u2022 Must be able to work in an office environment with minimal noise conditions. u2022 Must be able to work in Lab setting with exposure to Animals/biohazards / Chemicals (List specific Chemicals) u2022 Must not have animal allergies to applicable species in this facility u2022 Must be able to wear appropriate PPE u2022 Must be able to work in environment with variable noise levels u2022 Ability to stand /Sit/walk for long periods of time u2022 Ability to Lift 10 lbs routinely u2022 Ability to crouch, bend, twist, and reach u2022 Ability to push/pull 10 lbs routinely/ often / occasionally u2022 Clarity of Vision u2022 Ability to identify and distinguish colors u2022 Must be able to perform activities with repetitive motions u2022 Ability to climb Ladders / Stairs / Scaffolding u2022 Ability to work in variable temperatures high to freezing u2022 Inside/outside working conditions Anticipated base pay range: $128,552 to $167,239 An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management. Need help finding the right job? We can recommend jobs specifically for youAn Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disabilityAn Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability ( Job Locations _US-CA-San Diego_ Job ID _2026-13982_

Created: 2026-02-25