Oligonucleotide Scientist II

Description The Position: We are seeking a creative self-motivated collaborative Contractor/Scientist-II to join the Nucleic Acid Design and Discovery NADD team within ProteinSciences PS department at Genentech. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in delivery of oligonucleotide therapeutics large molecule drug discovery would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture. Key Responsibilities: The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas including neuroscience immunology and oncology to help build a comprehensive therapeutic discovery strategy. Good understanding and also troubleshooting experience in oligonucleotide synthesis impurity profiling is a plus. Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers HPLC and desalting units. Perform literature reviews propose and execute nucleic acid chemistry plans coordinate chemistry and biology data to support oligonucleotide compound progression. Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies. Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies. Skills oligonucleotide, oligo synthesizers, novel nucleic acid, chemistry, mass spectrometry, HPLC Top Skills Details oligonucleotide,oligo synthesizers,novel nucleic acid,chemistry,mass spectrometry,HPLC Additional Skills & Qualifications n/a Experience Level Intermediate Level Job Type & Location This is a Contract position based out of South San Francisco, CA. Pay and Benefits The pay range for this position is $40.00 - $42.00/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: u2022 Medical, dental & vision u2022 Critical Illness, Accident, and Hospital u2022 401(k) Retirement Plan u2013 Pre-tax and Roth post-tax contributions available u2022 Life Insurance (Voluntary Life & AD&D for the employee and dependents) u2022 Short and long-term disability u2022 Health Spending Account (HSA) u2022 Transportation benefits u2022 Employee Assistance Program u2022 Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a fully onsite position in South San Francisco,CA. Application Deadline This position is anticipated to close on Apr 3, 2026. Diversity, Equity & Inclusion At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I is embedded into our culture through: + Hiring diverse talent + Maintaining an inclusive environment through persistent self-reflection + Building a culture of care, engagement, and recognition with clear outcomes + Ensuring growth opportunities for our people Actalent is an equal opportunity employer. About Actalent Actalent is a global leader in engineering and sciences services. For more than 40 years, weu2019ve helped visionary companies advance their goals. Headquartered in the United States, our teams span 150 offices across North America, EMEA, and APACu2014with four delivery centers in India led by 1,000+ extraordinary employees who connect their passion with purpose every day. Our Bangalore, Hyderabad, Pune, and Chennai delivery centers are hubs of engineering expertise, with core capabilities in mechanical and electrical engineering, systems and software, and manufacturing engineering. Our teams deliver work across multiple industries including transportation, consumer and industrial products, and life sciences. We serve more than 4,500 clients, including many Fortune 500 brands. Learn more about how we can work together at .

Created: 2026-03-23