Sr. Upstream Processing Technician

Upstream Processing Technician Job Description We are seeking a dedicated Upstream Processing Technician to support the manufacture of Commercial and Clinical Biologics. The successful candidate will work within the Harvest Team and adhere to Current Good Manufacturing Practices (cGMPs) while carrying out various functions related to upstream cell culture processes. These functions include propagation of mammalian cell culture, conducting aseptic operations, executing large-scale production bioreactors, and performing large scale filtration or centrifugation. Additionally, the role involves manufacturing buffers and bulk reagents with limited supervision and participating in process improvement projects. PAY - $28/hour Responsibilities + Review all area documents to ensure accuracy and compliance. + Assist in the manufacture of controls and calibrators while completing batch records following cGMPs. + Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers. + Transfer, mix, and handle chemicals as required. + Conduct product filtrations and perform cleaning and steaming of steel tanks (CIP/SIP). + Prepare glassware and steel tanks for sterilization in autoclaves and operate the autoclave. + Maintain laboratory equipment, including pumps, pH meters, and flow meters. + Keep department lead or manager informed of all issues. + Monitor and manage stocks of common laboratory supplies. + Respond to emergency notifications promptly. + Work flexible hours, including weekends. Essential Skills + Minimum of 2 years of work experience in manufacturing, operations, production, lab setting, or related field. + Bachelor's Degree in Science with knowledge of aseptic techniques, cell culturing, and pipetting. + Experience in a cGMP environment is preferred. + Knowledge of cGMP practices, aseptic techniques, and chemical concepts is preferred. Additional Skills & Qualifications + Subject Matter Expert in upstream processing steps is preferred. + 6 months of experience in a GMP regulated environment is preferred. + 4-year STEM degree is preferred. Work Environment The work environment includes clean room/aseptic suites, requiring full gowning, which includes bodysuit, gloves, hair and beard nets, face covers, and safety glasses. Employees must be willing to work in rotating 12-hour shifts, with a schedule involving 7 working days over a 2-week period. The role requires the ability to lift a minimum of 25 lbs independently and the ability to stand for 80% of the shift. Personal items such as makeup, jewelry, nail polish, cologne/perfume, and scented lotions or hair care products are prohibited in this environment. Job Type & Location This is a Contract to Hire position based out of Saint Louis, MO. Pay and Benefits The pay range for this position is $28.00 - $28.00/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: u2022 Medical, dental & vision u2022 Critical Illness, Accident, and Hospital u2022 401(k) Retirement Plan u2013 Pre-tax and Roth post-tax contributions available u2022 Life Insurance (Voluntary Life & AD&D for the employee and dependents) u2022 Short and long-term disability u2022 Health Spending Account (HSA) u2022 Transportation benefits u2022 Employee Assistance Program u2022 Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a fully onsite position in Saint Louis,MO. Application Deadline This position is anticipated to close on Mar 31, 2026. Diversity, Equity & Inclusion At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I is embedded into our culture through: + Hiring diverse talent + Maintaining an inclusive environment through persistent self-reflection + Building a culture of care, engagement, and recognition with clear outcomes + Ensuring growth opportunities for our people Actalent is an equal opportunity employer. About Actalent Actalent is a global leader in engineering and sciences services. For more than 40 years, weu2019ve helped visionary companies advance their goals. Headquartered in the United States, our teams span 150 offices across North America, EMEA, and APACu2014with four delivery centers in India led by 1,000+ extraordinary employees who connect their passion with purpose every day. Our Bangalore, Hyderabad, Pune, and Chennai delivery centers are hubs of engineering expertise, with core capabilities in mechanical and electrical engineering, systems and software, and manufacturing engineering. Our teams deliver work across multiple industries including transportation, consumer and industrial products, and life sciences. We serve more than 4,500 clients, including many Fortune 500 brands. Learn more about how we can work together at .

Created: 2026-03-25