Sr. Downstream Processing Technician

Downstream Processing Technician III Job Description The Downstream Processing Technician III plays a key role in large-scale biological and chemistry pharmaceutical manufacturing operations, supporting the production of biologics such as proteins used in pharmaceutical products. This position focuses on the flawless execution of manufacturing batch records, work instructions, and SOPs in a cGMP-regulated cleanroom environment. The role requires strong attention to detail, adherence to aseptic techniques, and active participation in continuous improvement, quality investigations, and lean activities to ensure safe, efficient, and compliant operations. PAY - $28-$32/hour Responsibilities + Execute manufacturing batch records, work instructions, and SOPs with a strong focus on proactive, right-the-first-time performance. + Assist with batch record reconciliation to ensure complete, accurate, and compliant documentation. + Support all departmental functions, including maintaining manufacturing suites, supplies, equipment, logbooks, and data in accordance with site SOPs and policies. + Document all activities to meet cGMP requirements, including completing document reviews, revisions, and daily record reviews. + Update and maintain relevant databases and systems as part of routine documentation and tracking activities. + Actively provide feedback on processes, documentation, and operations to support continuous improvement. + Participate in and at times lead shift exchanges, one-on-one discussions, and team meetings to facilitate communication and address changing area needs, including lean activities. + Support quality investigations by answering questions, providing process information, and offering suggestions for improvement. + Practice and promote safe work habits by adhering to established safety procedures and guidelines at all times. + Critically evaluate processes with foresight, identifying potential issues and opportunities for improvement before they impact operations. + Interpret production schedules, prioritize tasks appropriately, and complete work in alignment with operational timelines. + Apply aseptic techniques and cleanroom practices consistently to protect product integrity and maintain compliance. + Handle and operate laboratory and downstream processing equipment in accordance with training and SOPs. + Contribute subject matter expertise in downstream processing steps, where applicable, to support technical discussions and process optimization. Essential Skills + Bacheloru2019s degree in a STEM-related field (Science, Technology, Engineering, or Mathematics) required. + Minimum of 2 years of work experience in manufacturing, operations, production, laboratory setting, or a related field. + Ability to execute and follow detailed manufacturing batch records, work instructions, and SOPs accurately. + Strong attention to detail with a proactive, right-the-first-time mindset. + Ability to document work clearly and completely to meet cGMP requirements. + Capability to interpret production schedules and prioritize tasks accordingly. + Proficiency in working in a regulated environment with adherence to site SOPs, policies, and safety guidelines. + Physical ability to lift a minimum of 25 lbs independently. + Ability to stand for approximately 80% of the shift. + Willingness and ability to work rotating 12-hour shifts, including nights and weekends, as scheduled. + Ability to meet cleanroom gowning requirements, including wearing full gowning suits and appropriate gloves. Additional Skills & Qualifications + Preferred: Experience in a cGMP-regulated environment. + Preferred: At least 6 months of experience in a GMP-regulated environment with aseptic technique. + Preferred: Four-year STEM degree with exposure to aseptic technique, chemistry, HPLC, chromatography, and pharmaceutical or pharmaceutical industry environments. + Familiarity with aseptic techniques and cleanroom operations. + Knowledge of cGMP practices, aseptic techniques, or chemical concepts. + Preferred: Subject matter expertise in downstream processing steps. + Experience with laboratory techniques related to chemistry and biologics is advantageous. + Strong communication skills to participate effectively in shift exchanges, one-on-one meetings, and team discussions. + Comfort with providing feedback and participating in continuous improvement and lean activities. Work Environment This role is based in a cleanroom and aseptic suite environment where you will work with large-scale biological and chemistry pharmaceutical operations. You will support the production of biologics, such as proteins used in pharmaceuticals for conditions including autoimmune diseases. The position requires full cleanroom gowning, including a bodysuit, gloves, hair and beard nets, face covers, and safety glasses. To maintain cleanroom standards, items such as makeup, jewelry, nail polish, cologne or perfume, and scented lotions or hair care products are not permitted. You must be able to wear Tyvek, nitrile, and/or latex gloves and meet all cleanroom gowning requirements. The role involves standing for most of the shift and lifting up to 25 lbs independently. Initial training is conducted Monday through Friday for approximately 4u20136 weeks, focusing on SOP and safety training. After initial training, the position transitions to rotating 12-hour shifts, working 7 days out of a 2-week period, with both day and night shifts in rotation. An example schedule includes working Mondayu2013Tuesday, off Wednesdayu2013Thursday, and working Fridayu2013Sunday in Week 1, then off Mondayu2013Tuesday, working Wednesdayu2013Thursday, and off Fridayu2013Sunday in Week 2. Starting in July, the schedule may transition to 10-hour shifts (40 hours per week) on a 3-2-2-2-3 pattern, with a strong likelihood of second shift (approximately 2:00 p.m.u201312:00 a.m.). The work environment emphasizes safety, collaboration with a team of experienced professionals, and exposure to advanced biopharmaceutical manufacturing technologies, offering a strong career development opportunity in large-scale biologics and pharmaceutical operations. Job Type & Location This is a Contract to Hire position based out of Saint Louis, MO. Pay and Benefits The pay range for this position is $28.00 - $32.20/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: u2022 Medical, dental & vision u2022 Critical Illness, Accident, and Hospital u2022 401(k) Retirement Plan u2013 Pre-tax and Roth post-tax contributions available u2022 Life Insurance (Voluntary Life & AD&D for the employee and dependents) u2022 Short and long-term disability u2022 Health Spending Account (HSA) u2022 Transportation benefits u2022 Employee Assistance Program u2022 Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a fully onsite position in Saint Louis,MO. Application Deadline This position is anticipated to close on May 1, 2026. Diversity, Equity & Inclusion At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I is embedded into our culture through: + Hiring diverse talent + Maintaining an inclusive environment through persistent self-reflection + Building a culture of care, engagement, and recognition with clear outcomes + Ensuring growth opportunities for our people Actalent is an equal opportunity employer. About Actalent Actalent is a global leader in engineering and sciences services. For more than 40 years, weu2019ve helped visionary companies advance their goals. Headquartered in the United States, our teams span 150 offices across North America, EMEA, and APACu2014with four delivery centers in India led by 1,000+ extraordinary employees who connect their passion with purpose every day. Our Bangalore, Hyderabad, Pune, and Chennai delivery centers are hubs of engineering expertise, with core capabilities in mechanical and electrical engineering, systems and software, and manufacturing engineering. Our teams deliver work across multiple industries including transportation, consumer and industrial products, and life sciences. We serve more than 4,500 clients, including many Fortune 500 brands. Learn more about how we can work together at .

Created: 2026-04-20