Principal Scientist, Large Molecules Mass Spectrometry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Weu2019re looking for people who are determined to make life better for people around the world. Organization Overview: The Bioanalytical Research Group (BAR) at Lillyu2019s research facility in Indianapolis, IN is seeking a strong scientist skilled in protein and oligonucleotide mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of therapeutic proteins and genetic medicine modalities. The team collaborates with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimal therapeutic candidates to advance to clinical testing. Primary Responsibilities: The development and application of QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and biodistribution of therapeutic proteins and new drug modalities in pre-clinical animal models. Serving as the bioanalytical representative with project teams to achieve project milestones. Prioritization of workload and mentoring staff scientists within a broad field bioanalytical team. Job Requirements: + M.S. in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or equivalent field and 4+ years of work experience (or a B.S. with 6+ years). + Experience developing and implementing orbitrap mass spectrometry applications to investigate the ADME properties of therapeutic proteins and new modalities (Large Molecules) + Experience with a wet biochemistry and sample preparation techniques involved in isolating biotherapeutics from biological matrices. + Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Preferred Qualifications: + Expertise in bioanalysis of siRNA or Antibody-Oligonucleotide Conjugates (AOC) is highly preferred. Experience assessing PK, Efficacy, and toxicology profiles in preclinical models and presenting data to project teams is highly desirable. + Knowledge of the ADME principles of biotherapeutic drugs. Experience with proteomics methods, DDA, nano-LC, DIA, or similar workflows in a drug discovery setting. Additional experience with automation, higher throughput methodologies, and biotransformation software tools. + Excellent written and verbal communication skills. Strong work planning, record keeping and data analysis skills Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Womenu2019s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidateu2019s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 - $193,600 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lillyu2019s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

Created: 2026-05-04